Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C-C chemokine receptor type 3 |
| Gene Name | CCR3 |
| Uniprot | P51677 (Human); P51678 (Mouse) |
| Synonym | CKR3; CD193; CKR 3; CMKBR3; C C CKR3; CC-CKR-3; C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CCR-3 |
| Background | CCR-3, alternatively known as eosinophil eotaxin receptor or CD antigen (CD193), belongs to family 1 of the G protein-coupled receptors for C-C type chemokines and it is encoded by CCR3 gene in human. Expression profiling reveals its prominent abundance primarily on eosinophils and basophils; however, discernible CCR3 levels are also detected on both TH1 and TH2 lymphocyte populations, in addition to airway epithelial cells. The transcript variants by alternatively spliced have been described. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX462 | NativeExtract™ Human CCR3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MP1332J | MemDX™ Membrane Protein Human CCR3 (C-C motif chemokine receptor 3) for Antibody Discovery | E.colicell-free | Full length | Detergent |
| S01YF-0423-KX574 | MemDX™ Membrane Protein Human CCR3 (1-34aa) Expressed in HEK293, C-Human Fc tag | HEK293 cells | Partial | N/A |
| Please for more products or customization | ||||
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs provides gene knockout and knockdown services. Eliminating the CCR3 gene in mice can suppress the growth, maturation, and movement of eosinophils. This methodology has been applied to explore the function of CCR3 in conditions such as allergic rhinitis and asthma, showing remarkable relief of clinical manifestations.
Creative Biolabs offers gene overexpression and genetic engineering services. Induced eosinopoiesis, achieved through genetic engineering strategies enforcing constitutive interleukin-5 (IL-5) overexpression in murine models, yielded significant therapeutic benefits. Specifically, this approach precipitated marked reductions in pleural tumor burden and malignant pleural effusion (MPE) volume, observations correlated with a twofold extension in median survival duration for these animals.
Creative Biolabs offers pathway inhibition research services. In murine models of allergic rhinitis, targeted silencing of the Ccr3 gene culminates in diminished eosinophilic inflammation alongside attenuated Th2 immune responses; this outcome is mechanistically coupled to the inhibition of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway. Such findings illuminate the therapeutic potential of interventions targeting intracellular signaling cascades operating downstream of CCR3 activation to modulate its physiological effects.
Creative Biolabs offers comprehensive and innovative services to drive the development of CCR3 cell therapy. Please for more services.
Creative Biolabs offers adoptive transfer of eosinophils research services. Transferring eosinophils into wild-type (WT) mice can reduce malignant pleural effusion (MPE) volume and pleural tumor burden. This method leverages the anti-tumor effects of eosinophils, which are recruited and activated by CCR3 ligands like CCL11.
Creative Biolabs offers genetic engineering for continuous eosinophil production services. This genetic modification results in sustained eosinophilia, which significantly reduces pleural tumor burden and MPE volume, and doubles the survival duration in mouse models.
Creative Biolabs is a leading specialty CRO providing state-of-the-art platforms in membrane protein preparation to our worldwide clients. We have been partnering with some of the largest pharmaceutical companies and many famous biotech companies, as well as world-top universities for years. Please feel free to for more details.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
