Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | C-C chemokine receptor type 7 |
| Gene Name | CCR7 |
| Uniprot | P32248 (Human); P47774 (Mouse) |
| Synonym | BLR2; EBI1; CCR-7; CD197; CDw197; CMKBR7; CC-CKR-7; C-C chemokine receptor type 7; Bukitt's lymphoma receptor 2; CC chemokine receptor 7; EBV-induced G protein-coupled receptor 1 |
| Background | CCR-7, also known as cluster of differentiation 197 (CD197), EBI1 or BLR2, is a membrane protein encoded by CCR7 gene. It is a member of the G protein-coupled receptor family, and is primarily expressed in various lymphoid tissues and activates B and T lymphocytes. CCR-7 has also been found in various cancer cells, such as nonsmall lung cancer, gastric cancer, and oesophageal cancer. This protein is supposed to be a mediator of Epstein-Barr virus (EBV) effects on B lymphocytes. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX460 | NativeExtract™ Human CCR7 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MP1336J | MemDX™ Membrane Protein Human CCR7 (C-C motif chemokine receptor 7) expressed in E.coli for Antibody Discovery | E.colicell-free | Full length | Detergent |
| MP0640J | MemDX™ Membrane Protein Human CCR7 (C-C motif chemokine receptor 7) for Antibody Discovery | HEK293 cells | Full length | N/A |
| MP0173X | MemDX™ Membrane Protein Human CCR7 (C-C motif chemokine receptor 7 expressed in in vitro wheat germ expression system) for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| Please for more products or customization | ||||
N**o: I recently purchased the CCR7 protein from Creative Biolabs, and I am extremely satisfied with my purchase. The protein arrived in perfect condition, and the quality exceeded my expectations. The shipping was fast, and the customer service was outstanding.
13/ Sep/2023
L***a: The support team was very knowledgeable and supportive, which made the entire process seamless. I am very impressed and will continue to rely on Creative Biolabs for my future needs. Highly recommended!
23/Apr/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Creative Biolabs offers isolation and enrichment of CCR7+ T cells services. Emerging evidence suggests that CCR7+ T cells, owing to their migratory specificity toward lymphoid chemokine gradients, may serve as optimal vectors for precision immunotherapy. The isolation process capitalizes on antigen-specific magnetic sorting, which segregates target cells with minimal perturbation to their functional integrity. Post-enrichment, cultured lymphocytes are often exposed to interleukin-2 (IL-2) or analogous growth factors to augment clonal expansion while preserving phenotypic stability. Such protocols aim to reconcile scalability with biological fidelity, though challenges persist in maintaining CCR7 expression fidelity during prolonged culture.
Creative Biolabs offers knockout mouse models. Murine systems harboring targeted Ccr7 genetic ablation serve as indispensable tools for dissecting the receptor's multifaceted roles in modulating tumor-immune crosstalk. By leveraging these knockout models, researchers can systematically delineate the mechanistic sequelae of CCR7 deficiency, particularly its influence on neoplastic ecosystem dynamics and adaptive immunity.
Creative Biolabs offers single-cell RNA sequencing services. Critically, the integration of multi-modal data underscores the receptor's context-dependent activities, which are often obscured in bulk sequencing analyses. This paradigm highlights the necessity of combinatorial experimental frameworks to disentangle CCR7's contributions to cellular crosstalk, angiogenesis, and immunoediting. Nevertheless, challenges persist in reconciling transcriptomic signatures with functional phenotypes, necessitating further validation through spatial proteomics or CRISPR-based perturbation studies.
Creative Biolabs offers comprehensive and innovative services to drive the development of CCR7 cell therapy. Please for more services.
Creative Biolabs offers chemokine-based CAR-T cell enrichment services. The activity of chemokine axes, such as the CCL19/CCL21-CCR7 axis, plays a critical role in the migration and infiltration of T cells into the tumor microenvironment (TME). Enhancing the activity of these axes can improve the antitumor efficacy of CAR-T cells.
Creative Biolabs offers tumor microenvironment research services targeting CCR7. Modifying the tumor microenvironment to enhance the activity of CAR-T cells is another promising strategy. Combining CAR-T cell therapy with radiotherapy can upregulate the expression of chemokines like CXCL16, which in turn enhances the infiltration of CAR-T cells into the tumor.
With the world's broadest range of knowledge in membrane protein, Creative Biolabs applies its expertise in professional membrane protein preparation of demanded formats by all sorts of strategies. In complement to our regular membrane protein preparation services, we also offer customized services based on the requirements of our clients. Please feel free to for detailed information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
