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HighlightsIntroduction of CDH5
CDH5, the full name being cadherin-5, is also known as 7B4 antigen, vascular endothelial cadherin (VE-cadherin) or CD144. It belongs to the superfamily of classical cadherins and as such, mediates homotypic calcium-dependent cell-cell interactions. CDH5 expression is tissue-specific and unique to endothelial cells.
| Basic Information of CDH5 | |
| Protein Name | Cadherin-5 |
| Gene Name | CDH5 |
| Aliases | 7B4 antigen, Vascular endothelial cadherin (VE-cadherin), CD144 |
| Organism | Homo sapiens (Human) |
| UniProt ID | P33151 |
| Transmembrane Times | 1 |
| Length (aa) | 784 |
| Sequence | MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY |
Function of CDH5 Membrane Protein
CDH5 is a component of endothelial cell-cell adhesion junctions that plays a key role in maintaining vascular integrity. It is one of the first cell-specific markers expressed by endothelial cells during embryonic vasculature development. Early expression of CDH5 in embryonic endothelial progenitor cells suggests that it contributes to endothelial differentiation. In addition, CDH5 contributes to the critical and specific functional properties of endothelial cells during angiogenesis. These include the establishment of cell polarity, the formation of a correct lumen, vascular tubulogenesis, rearrangement of the cytoskeleton, tight junction remodeling and gene transcription.
Fig.1 CDH5-mediated endothelial cell adhesion. (Giannotta, 2013)
Application of CDH5 Membrane Protein in Literature
Chlamydia pneumoniae infection promotes transendothelial migration of monocytes by increasing vascular endothelial cell permeability through tyrosine phosphorylation and VE-cadherin internalization in vascular endothelial cells.
The study shows a VE-cadherin-mediated cell dynamics and an endothelial-dependent proliferation in a differentiation-dependent manner.
By analyzing the tumor tissues of patients with advanced gastric adenocarcinoma undergoing gastrectomy, authors find that CDH5 may play a key role in the recurrence of advanced gastric cancer and may be a viable therapeutic target.
By using an affinity proteomics strategy, antibody suspension bead arrays are used to analyze plasma and serum samples from human DILI cases and controls. It is concluded that the expression levels of CDH5 and FABP1 are both elevated in drug-induced liver injury.
The article supports the general role of VE-cadherin and other RGD cadherins as key regulators of lung and liver metastasis in multiple solid tumors.
CDH5 Preparation Options
Membrane protein studies have advanced significantly over the past few years. Based on our versatile Magic™ membrane protein production platform, we could offer a series of membrane protein preparation services for worldwide customers in reconstitution forms or membrane protein analysis. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-CDH5 antibody development services.
During the past years, Creative Biolabs has successfully generated many functional membrane proteins for our global customers. We are happy to accelerate the development of our clients’ programs with our one-stop, custom-oriented service. For more detailed information, please feel free to contact us.
Reference
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