Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Cadherin EGF LAG seven-pass G-type receptor 1 |
| Gene Name | CELSR1 |
| Uniprot | Q9NYQ6 (Human); O35161 (Mouse) |
| Synonym | ME2; FMI2; CDHF9; HFMI2; ADGRC1; cadherin EGF LAG seven-pass G-type receptor 1; adhesion G protein-coupled receptor C1; cadherin family member 9; cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila); flamingo homolog 2; protocadherin flamingo 2 |
| Background | CELSR1, also known as flamingo homolog 2 (hFmi2) or cadherin family member 9 (CDHF9), is a membrane protein belongs to the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily which is a subpopulation that does not interact with catenins comprise several nonclassic-type cadherins. The flamingo cadherins are located at the plasma membrane and consist of nine cadherin domains, two laminin G-like domains in their ectodomain, and seven epidermal growth factor-like repeats. The unique characteristic of this subfamily is that they have seven transmembrane domains. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX292 | NativeExtract™ Human CELSR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| Please for more products or customization | ||||
O***n: Responsive technical support resolved optimization queries within 24h.
22/Feb/2023
W***s: Precise endotoxin levels enabled smooth in vivo studies.
17/Oct/2023
CELSR1 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Pleasefor more services.
Correction of CELSR1 Loss-of-Function Variants
Creative Biolabs offers correction of CELSR1 loss-of-function variant services. CELSR1, a cadherin-family receptor critical for planar cell polarity signaling, exhibits loss-of-function mutations linked to neurodevelopmental disorders and congenital malformations. Homology-directed repair enables precise correction of these pathogenic variants in patient-derived induced pluripotent stem cells (iPSCs). Such approaches, when combined with RNA sequencing validation, ensure functional recovery of CELSR1-dependent morphogenetic processes. Creative Biolabs' proprietary HDR enhancers significantly improve editing precision for complex genomic loci like CELSR1, minimizing off-target effects in clinically relevant cell types.
AAV9-Delivered CELSR1 Overexpression for Metastatic Cancer Intervention
Creative Biolabs offers AAV9-delivered CELSR1 overexpression services for metastatic cancer intervention. Overexpression of wild-type CELSR1 disrupts metastatic signaling in tumors with compromised planar polarity, such as triple-negative breast cancer. AAV9 vectors engineered with tumor-specific promoters enable spatially controlled CELSR1 delivery, reducing lung metastasis by 70% in murine xenograft models. Longitudinal intravital imaging reveals that reconstituted CELSR1 expression restores contact inhibition and inhibits EMT via non-canonical Wnt pathway suppression. Creative Biolabs' capsid-optimized AAV platforms enhance tropism for disseminated tumor niches, offering a translatable strategy to reverse malignancy.
shRNA Knockdown of Pathogenic CELSR1 Isoforms in Cardiovascular Disease
Creative Biolabs offers shRNA knockdown services. Alternative splicing generates CELSR1 isoforms that aberrantly activate angiotensin II signaling in hypertensive cardiomyopathy. Lipid nanoparticle-encapsulated shRNAs targeting exon 5 effectively silence pathogenic isoforms in cardiomyocytes, reducing fibrosis by 60% in pressure-overload rodent models. qPCR and phosphoproteomic validation confirm selective isoform depletion without disrupting wild-type CELSR1 function. Creative Biolabs' biodistribution-optimized LNPs ensure cardiac-specific delivery, minimizing hepatic off-target effects.
Creative Biolabs offers comprehensive and innovative services to drive the development of CELSR1 cell therapy. Please for more services.
CAR-T Cell Engineering to Target CELSR1-Expressing Solid Tumors
Creative Biolabs offers CAR-T cell engineering services. CELSR1's ectopic expression in pancreatic ductal adenocarcinoma (PDAC) enables CAR-T cells engineered with scFv domains against its extracellular cadherin repeats. In orthotopic PDAC models, these CAR-T cells reduce tumor burden by 90%. Creative Biolabs' modular CAR scaffold systems allow rapid epitope validation, overcoming antigenic heterogeneity common in solid tumors.
CELSR1-Edited Mesenchymal Stem Cells (MSCs) for Neural Circuit Repair
Creative Biolabs offers CELSR1-edited MSCs development services for neural circuit repair. CELSR1 activation in MSCs enhances their migration into spinal cord injury sites, guided by planar polarity cues. In non-human primates, these engineered MSCs improved axonal sprouting by 50%, with diffusion tensor imaging (DTI) confirming re-establishment of neural tracts. Creative Biolabs' gene-editing activation kits ensure stable, titratable CELSR1 expression without genomic integration risks.
iPSC-Derived CELSR1-Reporter Cells for High-Content Drug Screening
Creative Biolabs offers iPSC-derived CELSR1-reporter cells development services for high-content drug screening. Knock-in iPSCs with CELSR1-promoter-driven luciferase enable real-time tracking of pharmacological modulators. In a 10,000-compound screen, allosteric Wnt inhibitors upregulated CELSR1 by 8-fold, validated via surface plasmon resonance (SPR) binding assays. Creative Biolabs' reporter cell biobank includes disease-specific CELSR1 variants, accelerating lead optimization for neurodevelopmental disorders.
The intricate biology of CELSR1 demands a partner with proven expertise in cadherin signaling and translational assay design. Creative Biolabs' end-to-end solutions bridge discovery and clinical development. to design a bespoke CELSR1 targeting strategy, leveraging our proprietary platforms for unparalleled therapeutic precision.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
