Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Cadherin EGF LAG seven-pass G-type receptor 2 |
| Gene Name | CELSR2 |
| Uniprot | Q9HCU4 (Human); Q9R0M0 (Mouse) |
| Synonym | EGFL2; MEGF3; ADGRC2; CDHF10; Flamingo1; cadherin EGF LAG seven-pass G-type receptor 2; EGF-like protein 2 EGF-like-domain, multiple 2; adhesion G protein-coupled receptor C2; cadherin family member 10; cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); epidermal growth factor-like 2; epidermal growth factor-like protein 2; flamingo homolog 3; multiple EGF-like domains protein 3; multiple epidermal growth factor-like domains 3; multiple epidermal growth factor-like domains protein 3 |
| Background | CELSR2, encoded by CELSR2 gene, is a member of the flamingo subfamily, one of the cadherin superfamily. The extracellular domain of flamingo cadherins is very large, consist of nine N-terminal repeated cadherin domains, seven epidermal growth factor-like repeats, two laminin A G-type repeats, a hormone receptor motif and a G-protein-coupled receptor proteolytic site. The flamingo cadherins also have seven transmembrane domains which are unique structural feature of the subfamily. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX291 | NativeExtract™ Human CELSR2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| Please contact us for more products or customization | ||||
I***de: Flawless custom expression of CELSR2 extracellular domain with tailored glycosylation.
13/Jul/2023
J***a: Expert technical support ensured optimal buffer formulation.
06/Mar/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
AAV-Mediated CELSR2 Allele-Specific Expression Modulation
Creative Biolabs offers AAV-mediated CELSR2 allele-specific expression modulation services. Adeno-associated virus (AAV) vectors engineered for cell-specific CELSR2 targeting enable precise genomic integration of therapeutic constructs. For instance, liver-tropic AAV9 variants have been deployed to deliver wild-type CELSR2 transcripts in preclinical models of metabolic disorders caused by CELSR2 haploinsufficiency. Creative Biolabs' proprietary AAV capsid optimization platform enhances tropism for endothelial cells—a critical site of CELSR2 activity in vascular development. Such advancements allow researchers to achieve tissue-restricted expression, minimizing off-target effects while restoring functional pathways.
CELSR2 Regulatory Element Editing
Creative Biolabs offers CELSR2 regulatory element editing services. Dysregulation of CELSR2's noncoding regulatory regions has been implicated in neurodevelopmental pathologies. Gene editing systems, with their enhanced specificity for GC-rich sequences, facilitate precise base editing within CELSR2 promoter regions. This approach has demonstrated >85% efficiency in upregulating CELSR2 transcription in glioblastoma cell lines, as validated through RNA sequencing analyses. Creative Biolabs' integrated gene-editing design and validation services ensure locus-specific targeting, enabling researchers to dissect genotype-phenotype relationships with unprecedented resolution.
Creative Biolabs offers comprehensive and innovative services to drive the development of CELSR2 cell therapy. Please for more services.
CELSR2-Engineered CAR-T Cells for Solid Tumor Microenvironment Remodeling
Creative Biolabs offers CELSR2-engineered CAR-T cells development services for solid tumor microenvironment remodeling. Chimeric antigen receptor (CAR)-T cells expressing CELSR2-derived tumor-homing peptides exhibit enhanced penetration into desmoplastic tumor stroma. Recent trials leveraging this strategy achieved a 40% reduction in extracellular matrix density in pancreatic adenocarcinoma models. Creative Biolabs' lentiviral transduction protocols streamline the generation of such engineered T-cell populations while maintaining robust cytotoxic activity.
CELSR2-Positive iPSC-Derived Vascular Progenitors
Creative Biolabs offers CELSR2-positive iPSC-derived vascular progenitors development services. Induced pluripotent stem cells (iPSCs) differentiated into CELSR2-expressing endothelial progenitors have shown efficacy in restoring cerebral vasculature integrity post-ischemia. Through Creative Biolabs' proprietary differentiation matrices, these progenitors achieve >90% CELSR2 expression fidelity, critical for guiding angiogenic sprouting in 3D bioprinted tissue constructs.
Leverage Creative Biolabs' end-to-end solutions in viral vector design, gene-editing optimization, and cell therapy manufacturing to overcome biological complexities. Our platform integrates cutting-edge cell analytics and modular experimental workflows, ensuring rapid translation from target validation to IND-enabling studies. to explore tailored strategies for your CELSR2-focused programs.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
