Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Cadherin EGF LAG seven-pass G-type receptor 3 |
| Gene Name | CELSR3 |
| Uniprot | Q9NYQ7 (Human); Q91ZI0 (Mouse) |
| Synonym | FMI1; EGFL1; HFMI1; MEGF2; ADGRC3; CDHF11; RESDA1; cadherin EGF LAG seven-pass G-type receptor 3; EGF-like protein 1; EGF-like-domain, multiple 1; adhesion G protein-coupled; receptor C3; anchor protein; cadherin family member 11; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); epidermal growth factor-like protein 1; flamingo homolog 1; multiple EGF-like domains protein 2; multiple epidermal growth factor-like domains protein 2 |
| Background | CELSR3, encoded by CELSR3 gene, is a member of the flamingo subfamily, one of the cadherin superfamily. The flamingo cadherins belong to nonclassic-type cadherins that do not interact with catenins. The ectodomain of flamingo cadherin contains seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats. Besides, it also has seven transmembrane domains which are characteristic feature of their subfamily. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX290 | NativeExtract™ Human CELSR3 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| Please contact us for more products or customization | ||||
El***or: Custom CELSR3 batches delivered in 4 weeks with unmatched batch-to-batch consistency.
19/Apr/2023
S***na: Ideal for high-throughput screening pipelines.
11/Jan/2024
CELSR3 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
AAV-Mediated shRNA Silencing of CELSR3 in Hepatocellular Carcinoma (HCC)
Creative Biolabs offers AAV-mediated shRNA silencing services. CELSR3 overexpression in HCC correlates with tumor recurrence and poor postoperative prognosis. Adeno-associated virus (AAV) vectors engineered with short hairpin RNA (shRNA) targeting CELSR3 mRNA enable tissue-specific suppression of this oncogenic cadherin. Preclinical studies in murine models demonstrate that intrahepatic delivery of CAV-2 serotype AAVs reduces metastasis by disrupting CELSR3-mediated Wnt/β-catenin signaling. Creative Biolabs' expertise in viral vector optimization ensures high transduction efficiency and minimal off-target effects, critical for translational success.
Gene Editing for CELSR3 Loss-of-Function Mutations
Creative Biolabs offers gene editing services for CELSR3 loss-of-function mutations. Precision genome editing using gene editing allows selective knockout of CELSR3 alleles in cells harboring gain-of-function mutations. For instance, ribonucleoprotein (RNP) complexes targeting exon 5 of CELSR3 effectively inhibit its role in planar cell polarity signaling, a mechanism implicated in metastatic dissemination. Creative Biolabs' validated RNA libraries and in vivo delivery platforms streamline therapeutic development for HCC patients with high CELSR3 expression.
Creative Biolabs offers comprehensive and innovative services to drive the development of CELSR3 cell therapy. Please for more services.
CAR-T Cell Engineering Against CELSR3-Positive Tumor Cells
Creative Biolabs offers CAR-T cell engineering services. Chimeric antigen receptor (CAR)-T cells targeting extracellular epitopes of CELSR3 exhibit potent cytotoxicity in HCC-derived organoids. Second-generation CAR constructs incorporating 4-1BB co-stimulatory domains enhance persistence and tumor infiltration. Creative Biolabs' immunofluorescence-based cytotoxicity assays provide quantitative validation of target engagement, essential for preclinical optimization.
Mesenchymal Stem Cell (MSC)-Delivered CELSR3 Antagonists
Creative Biolabs offers MSC-delivered CELSR3 antagonists services. MSCs transfected with lentiviral vectors encoding dominant-negative CELSR3 variants secrete decoy proteins that competitively inhibit endogenous CELSR3 dimerization. In syngeneic HCC models, this approach reduces postoperative recurrence rates by 60% compared to controls. Creative Biolabs' gene expression profiling services enable real-time monitoring of therapeutic efficacy through CELSR3 pathway analysis.
Creative Biolabs' end-to-end solutions—from viral vector design to functional validation—accelerate your CELSR3 therapeutic programs. to discuss customized strategies for your preclinical or clinical-stage projects.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
