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Chemoselective Ligation Service

Creative Biolabs provides powerful chemoselective ligation service for protein engineering and modification based on the understanding of the target’s structures and the corrected properties. Scientists of Creative Biolabs are professional in chemoselective ligations and confident in offering the best protein engineering services to our global customers.

The modification of proteins has many applications, ranging from the study of natural post-translational modifications to the development of protein-based materials. However, the selective modification of proteins has been a challenge of modern chemical biology for a long time. There has developed many modification approaches to improve bioavailability and pharmacokinetics of protein-based drugs and study of protein expression and localization. In order to generate peptides and proteins with larger sizes, it is necessary to employ chemoselective ligation reactions.

Importance of chemoselective ligation reactions

Chemoselective ligation reactions are highly effective and specific covalent bond forming reactions which are capable of proceeding within a physiological environment. Commonly, chemoselective ligation reactions could create long peptides or protein chains and generate a unique product. In these reactions, two mutually reactive functional groups undergo a chemoselective reaction independent of all the unprotected functional groups borne by the amino acid side chains. It is similar to enzymatic reactions with exquisite specificity. In addition to the high specificity, chemoselective ligation reactions show important advantages, which allow a broader range of partners to perform reactions. Because of the unique characteristics, chemoselective ligation reactions have been used in many applications, such as carbohydrate-based structure construction, cell-surface engineering, generation of glycoproteins/peptides and glycosylated natural products.

Chemoselective Ligation Service Fig.1 Concept of peptide chemoselective ligation reactions (Harmand et al. 2014).

Creative Biolabs has developed advanced chemoselective ligation methods. It enables the selective modification of proteins and other biomolecules in dilute aqueous solution. More importantly, these reactions occur at the physiological environment in which pH equals 7.4. They also allow conjugation reactions to be carried out on unprotected substrates and improve the reaction rates even in some complex biological systems.

With these powerful technologies, Creative Biolabs provides a variety of chemoselective ligation services, including but not limited to:

Creative Biolabs has rich experience in protein engineering. With a full understanding of the technologies and the specific requirements of every client, scientists of Creative Biolabs could provide custom services to assist our customers’ protein engineering projects. For more information, please feel free to contact us for a detailed inquiry.


  1. Harmmand TJ.; et al. New chemistries for chemoselective peptide ligations and the total synthesis of proteins. Curr Opin Chem Biol. 2014, 22:115-121.

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