Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsChloride channel (CLC) family is a functionally and structurally diverse group of anion-selective channels which participate in cellular processes, such as the regulation of excitability of skeletal, neurons, cardiac and smooth muscle, transepithelial salt transport, cell volume regulation, cell cycle and apoptosis, and the acidification of internal and extracellular compartments. Except for the transmitter-gated GABA and glycine receptors, the well-characterized CLCs can be divided into certain members of the voltage-sensitive subfamily, calcium-activated channel, high-conductance channel, volume-regulated channel, and the cystic fibrosis transmembrane conductance regulator (CFTR). CLCs show the permeability sequence at physiological pH as Cl- > Br- > I-. The expression of the Cl- transporter is regulated both temporally and spatially so that the rest of the intracellular Cl- is dynamically modulated. Dramatic changes in intracellular Cl- have been documented to occur both slowly during development and more acutely in response to synaptic activity.
Here shows part of CLC members in humans in the chart. The CLC family contains 10-12 transmembrane helices and each protein has the ability to form a single pore. The mammalian CLC family consists of nine members that fall into three subfamilies. Among them, CLCN1 is implicated in setting and restoring the resting membrane potential of skeletal muscle, while others play important roles in the solute concentration mechanism for the kidney.
Assisted with versatile MemDX™ membrane protein production platform, Creative Biolabs is willing to provide the preparation of protein targets you need by using various strategies, for instance, detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery system can help customers to discover antibodies against these membrane proteins, even fully humanized antibodies, via diverse approaches involving hybridoma technology, phage display technology, and so like. Besides, we also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
