Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsChinese hamster ovary (CHO) transient expression system is a preferred choice for biopharmaceuticals production for pre-project assessment and preclinical evaluation. As an undisputed global leader in drug discovery and manufacturing, Creative Biolabs provides our valued clients with customized CHO transient expression systems for comprehensive developability assessment of a variety of biological candidates.
The transient gene expression system is the dissociative plasmid or DNA fragments in cells can be expressed in large quantities at the early stage of transient transfection, which is also an increasingly important method for rapid preparation of recombinant proteins in cells. CHO cell lines are the most widely used mammalian system for recombinant protein transient expression and production since the first CHO-derived therapeutic protein (tissue plasminogen activator, tPA) was approved in 1986. The reason why CHO cell lines are developed as a preferably chosen transient expression system may involve:
Fig.1 A summary of the many elements that need to be considered for the development of a rapid and economical mammalian expression system. (Hunter, 2019)
Good protein productibility by expression systems is essential for all subsequent test experiments and manufacturability assessment. To obtain candidate proteins in milligrams to gram quantities at the early stage of a project, CHO transient expression system is preferred and recommended choice because of high speed and low cost-consuming. Firstly, it ensures that candidate proteins transient expressed by CHO with high titer and good purification efficiency will be selected. Moreover, CHO transient expression system also allows for protein engineering experiments, growth parameter improvements, structure optimization, and product feasibility assessments. In addition, by different CHO systems in parallel, cell lines that most suitable for clinical and commercial production will be identified.
Based on our well-established mammalian (non-human) cell lines platform and CreDA™ platform, Creative Biolabs provides productivity assessment services of various biologic candidates using engineered CHO cell lines. If you are interested in the CHO productivity assessment for manufacturability optimization, just feel free to contact us for more detailed communications and information.
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
