Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Cholinergic receptor muscarinic 1 |
| Gene Name | CHRM1 |
| Uniprot | P11229 (Human); P12657 (Mouse) |
| Synonym | M1; HM1; M1R; muscarinic acetylcholine receptor M1; acetylcholine receptor, muscarinic 1 |
| Background | CHRM1, encoded by CHRM1 gene, is a member of G protein-coupled receptors family. It is coupled with G proteins of class Gq and possesses seven transmembrane domain. The protein is a muscarinic receptor that is used as a therapeutic target for treatment of Alzheimer disease. And many therapeutic drugs and other substances are made by selecting CHRM1 as agonists or antagonists. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX335 | NativeExtract™ Human CHRM1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3589K | MemDX™ Membrane Protein Human CHRM1 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
S**a: Their team of scientists is not only highly knowledgeable but also incredibly responsive. They were always available to address my questions and concerns, providing detailed explanations and guidance whenever needed.
23/Sep/2023
D*n: The customized solutions they provided were perfectly tailored to our specific needs, and their attention to detail was remarkable.
17/Jul/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Gene Expression Comparison
Creative Biolabs offers gene expression comparison services. An initial investigation centered on the transcriptional landscape within the cerebral cortex of mice genetically deficient in the cholinergic receptor muscarinic 1 (Chrm1-/-). The resultant alterations in gene expression profiles were subsequently juxtaposed with analogous transcriptomic variations documented in individuals diagnosed with schizophrenia. Furthermore, in a distinct analytical thrust, those genes exhibiting modified expression levels within the Chrm1-/- murine model underwent rigorous comparative analysis against genetic loci robustly associated with human cognitive capabilities, as previously delineated by comprehensive genome-wide association studies.
Creative Biolabs offers comprehensive and innovative services to drive the development of CHRM1 cell therapy. Please for more services.
Lentiviral Knockdown Models
Creative Biolabs offers lentiviral knockdown models development services. Lentiviral transduction was systematically employed to engineer prostate carcinoma cell lines exhibiting attenuated expression of both CHRM1 and Atg5. To achieve this targeted gene silencing, the designated cells underwent transduction with lentiviral constructs. These constructs were specifically designed to deliver short hairpin RNAs (shRNAs) capable of recognizing and mediating the degradation of CHRM1 and Atg5 messenger RNA transcripts. Subsequent to this genetic manipulation, the application of puromycin served as a stringent selection method, facilitating the isolation and ensuing propagation of stable cell populations that had successfully integrated the shRNA sequences.
Phenotypic Screening
Creative Biolabs offers phenotypic screening services. The functional interrogation of the CHRM1 gene, pursued through a phenotypic screening paradigm, initially involved the polymerase chain reaction (PCR)-based amplification of its coding sequence directly from genomic DNA templates. This amplified genetic material was subsequently engineered for heterologous expression within selected mammalian cellular systems. Such a methodological approach proved instrumental. It specifically enabled the delineation of putative pharmacological targets related to CHRM1 function and, furthermore, provided a framework for assessing the consequential repercussions of their potential modulation on fundamental cellular physiology.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
