Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Cholinergic receptor muscarinic 4 |
| Gene Name | CHRM4 |
| Uniprot | P08173 (Human); P32211 (Mouse) |
| Synonym | HM4; M4R; muscarinic acetylcholine receptor M4; acetylcholine receptor, muscarinic 4 |
| Background | CHRM4, encoded by CHRM4 gene, is a member of G protein-coupled receptors family which has seven distinctive transmembrane domains. It is one of five subtypes of muscarinic receptors (CHRM1-5), selectively expressed in various human tissues. It has been found that muscarinic receptors are the potential therapeutic targets for a variety of pathological conditions, especially in neurodegenerative disorders. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX333 | NativeExtract™ Human CHRM4 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3607K |
MemDX™ Membrane Protein Human CHRM4 Expressed in vitro E.coli expression system, Full Length |
E.coli cell-free | Full length | Detergent |
| MP0220X | MemDX™ Membrane Protein Human CHRM4 (Cholinergic receptor muscarinic 4) for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
E***n: Their team was highly professional, responsive, and delivered high-quality results within the promised timeline.
16/Apr/2023
H***y: Not only did Creative Biolabs provide top-notch protein engineering services, but they also supplied comprehensive documentation and technical support throughout the project.
03/Aug/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Promoter Reporter Vector Construction
Creative Biolabs offers promoter reporter vector construction services. To investigate the regulatory landscape of the CHRM4 gene, the initial step involves engineering specific reporter constructs. These constructs will feature promoter sequences derived from the CHRM4 gene itself, critically incorporating defined response elements; furthermore, they will utilize a green fluorescent protein (GFP) as the quantifiable reporter system. Subsequently, such precisely designed molecular tools are intended to facilitate a comprehensive examination.
Gene Editing
Creative Biolabs offers gene editing services. Precise genomic alterations targeting the CHRM4 gene are to be introduced employing advanced gene-editing methodologies. This strategic approach is designed to facilitate the generation of specific, defined mutations or, indeed, complete gene knockouts within relevant cellular systems or appropriate in vivo animal models. Subsequently, such genetically engineered models are anticipated to be instrumental. They should allow for a rigorous investigation into the functional involvement of CHRM4 in diverse disease etiologies and, furthermore, may prove invaluable for exploring its potential as a tractable therapeutic target.
Creative Biolabs offers comprehensive and innovative services to drive the development of CHRM4 cell therapy. Please for more services.
Stem Cell Engineering
Creative Biolabs offers stem cell engineering services. The therapeutic potential of distinct stem cell populations, notably induced pluripotent stem cells (iPSCs) or mesenchymal stem cells (MSCs), warrants rigorous investigation concerning their targeted utility. A compelling strategy involves the precise genetic modification of these cellular entities to achieve either controlled expression or functional modulation of the Cholinergic Receptor Muscarinic 4 (CHRM4). Subsequent to such bioengineering, these manipulated stem cells can then be meticulously guided towards differentiation into specific somatic lineages.
Tissue Engineering
Creative Biolabs offers tissue engineering services. A further strategic imperative involves the generation of three-dimensional (3D) tissue constructs or sophisticated organoid systems. These advanced in vitro models would be meticulously engineered to incorporate cellular components exhibiting specifically tailored expression profiles of the Cholinergic Receptor Muscarinic 4 (CHRM4). The principal advantage of such bioengineered analogues resides in their capacity to furnish a microenvironment that more closely recapitulates in vivo physiology. Consequently, these platforms are posited to be invaluable for the detailed elucidation of nuanced, tissue-specific effects arising from CHRM4 activity modulation and, perhaps more crucially, for the rigorous assessment of potential therapeutic applications with enhanced translational relevance.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
