Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Cholinergic receptor muscarinic 5 |
| Gene Name | CHRM5 |
| Uniprot | P08912 (Human); Q920H4 (Mouse) |
| Synonym | HM5; muscarinic acetylcholine receptor M5; acetylcholine receptor, muscarinic 5 |
| Background | CHRM5, encoded by CHRM5 gene, is a member of G protein-coupled receptors family which has seven distinctive transmembrane domains. It is one of five subtypes of muscarinic receptors, M1-M5, widely expressed on the numerous cell types in the central nervous system. It has been shown that muscarinic receptors are the promising treatment targets for a number of pathological conditions of the central nervous system. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX332 | NativeExtract™ Human CHRM5 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| MPX3623K |
MemDX™ Membrane Protein Human CHRM5 Expressed in vitro E.coli expression system, Full Length |
E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
J***an: Their team was communicative and ensured smooth logistics. Will definitely order from them again!
19/Oct/2023
We provide tailored solutions to meet your specific requirements. Please for more services.
DNA Methylation Analysis
Creative Biolabs offers DNA methylation analysis services. The systematic characterization of the DNA methylation status of the CHRM5 gene across a spectrum of diverse disease states is particularly warranted. Such investigations would strategically employ robust analytical techniques, prominently including quantitative methylation-specific polymerase chain reaction (qMSP), although recourse to other complementary genomic or epigenomic methodologies may also prove informative. The data derived from these rigorous analyses are anticipated to provide critical insights into the intricate epigenetic regulatory mechanisms governing CHRM5 expression. Furthermore, and perhaps more consequentially for translational science, these findings could substantially inform the evaluation of CHRM5 as a potential, and possibly druggable, therapeutic target in specific pathological contexts.
Epigenetic Editing
Creative Biolabs offers epigenetic editing services. These platforms, which are typically engineered by functionally coupling programmable DNA-targeting modules with potent epigenetic modifying enzymes, can be precisely directed to effect targeted alterations within the epigenetic landscape of specific genomic loci, such as that encompassing the CHRM5 gene. The application of such precision epigenetic perturbation is posited to be instrumental. Indeed, this approach may not only facilitate a more nuanced dissection of the fundamental role that distinct epigenetic modifications play in the intricate regulatory control of CHRM5 expression but could also critically illuminate the prospective therapeutic potential inherent in selectively rewriting these epigenetic signatures.
Polymorphism Screening
Creative Biolabs offers polymorphism screening services. A comprehensive interrogation for the presence of polymorphisms within the CHRM5 gene locus represents a crucial line of inquiry for understanding its role in health and disease. This endeavor would necessitate the systematic application of robust variant detection methodologies; these may range from established techniques such as denaturing high-performance liquid chromatography (DHPLC) to more exhaustive, high-throughput approaches like next-generation sequencing (NGS). The subsequent identification and, critically, the functional characterization of any discovered CHRM5 sequence variations are of paramount importance.
Creative Biolabs offers comprehensive and innovative services to drive the development of CHRM5 cell therapy. Please for more services.
Animal Model Development
Creative Biolabs offers animal model development services. The generation of genetically engineered animal models exhibiting specific alterations in CHRM5 expression represents a pivotal strategy for biomedical research. Such in vivo systems are posited to be indispensable tools, perhaps uniquely suited, for the rigorous elucidation of the physiological and pathophysiological roles of CHRM5 across a diverse spectrum of disease states. Illustratively, compelling evidence derived from rodent studies has firmly implicated CHRM5 as a critical regulator of sustained dopamine efflux in specific brain regions. This particular neurobiological phenomenon is not only well-documented but is also considered to bear significant relevance to, and may even contribute mechanistically to, the complex neurocircuitry dysfunctions observed in schizophrenia.
Bone Marrow Transplantation
Creative Biolabs offers bone marrow transplantation services. A powerful experimental paradigm for dissecting gene functions in vivo involves the adoptive transfer of bone marrow-derived cells. Specifically, hematopoietic stem and progenitor cells harvested from murine strains, such as those harboring a targeted null mutation of the CHRM5 gene or, indeed, other pertinent genetically engineered mouse models, can be transplanted into appropriately conditioned recipient animals. Such hematopoietic reconstitution in chimeric mouse models is posited to be exceptionally informative. Consequently, the systematic investigation of these systems may not only elucidate the intrinsic contribution of CHRM5 to the complex regulatory networks governing hematopoiesis but could also, perhaps, reveal novel therapeutic strategies for various hematological disorders by assessing the functional impact of CHRM5 deficiency or altered activity within the engrafted hematopoietic compartment.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
