Introduction of CHRNA3
CHRNA3, also known as neuronal acetylcholine receptor subunit alpha-3 (NACHRA3), is a subunit in neuronal acetylcholine receptor (nAChRs) and is encoded by the CHRNA3 gene. nAChRs are ligand-gated ion channels activated by acetylcholine and nicotine, mediating synaptic transmission in brain and diverse functions in the periphery. nAChR is thought to be composed of different permutations of nine α subunits (α2–α10) and three β subunits (β2–β4) in humans. Some of these subunits form homopentameric receptors when expressed in heterologous expression systems (α7, α8 or α9), whereas other subunits assemble into heteropentameric structures with various combinations of α and β subunits. They form a dynamic structure which is able to adopt several conformational states responsible for different functional characteristics.
|Basic Information of CHRNA3|
|Protein Name||Neuronal acetylcholine receptor subunit alpha-3|
|Organism||Homo sapiens (Human)|
Function of CHRNA3 Membrane Protein
nAChRs assembled with different subunits may mediate different physiological functions. The α3-containing nAChRs subtype plays a pivotal role in regulating the inflammatory responses in endothelial cells and macrophages. In addition, several single nucleotide polymorphisms (SNPs) in NACHRA3 is identified to be associated with chronic obstructive pulmonary disease based on a Norwegian population. Moreover, both the CHRNA3 and CHRNA5 genes are expressed in areas of the human brain associated with addiction, such as the nucleus accumbens, amygdala and entorhinal cortex. The α3 and α5 subunits are obligate accessory subunits which cannot form functional nAChRs by themselves or in combination with only one other type of subunit. Moreover, the α3, α5 and β4 gene clusters are involved in the ethanol-induced stimulation and nicotine effects and play an important role in this process.
Fig.1 Schematic representation of an individual nAChR subunit protein. (Scofield. 2010)
Application of CHRNA3 Membrane Protein Literature
This article reports that the α3, β4 and α5 subunits are clustered in genomes of different species, with the transcription factor Sp1 playing a coordinating role in the transcriptional regulation of these three subunits.
This article describes that Chrna3 is a candidate gene for the acute locomotor stimulant response to ethanol that deserves further examination.
This article suggests that common variants near the apolipoprotein E and CHRNA5 genes are associated with lifespan and a locus near CHRNA3/5 differentially affecting paternal lifespan.
This article suggests that CHRNA3, allele G of rs3743078 is associated with increased craving, CPD, and FTND scores and participants with several copies of the G allele smoke more cigarettes.
This article indicates that α3-nAChRs play a pivotal role in regulating the inflammatory responses in endothelial cells and macrophages and the mechanisms involve the modulations of multiple cell signaling pathways.
CHRNA3 Preparation Options
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All listed customized services & products are for research use only, not intended for pharmaceutical, diagnostic, therapeutic or any in vivo human use.