Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Cannabinoid receptor 1 |
| Gene Name | CNR1 |
| Uniprot | P21554 (Human); P47746 (Mouse) |
| Synonym | CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5; cannabinoid receptor 1 (brain); central cannabinoid receptor |
| Background | CNR1, encoded by CNR1 gene, belongs to a member of G protein-coupled cannabinoid receptors with seven transmembrane domains, an extracellular N-terminal and an intracellular C-terminal. It is one of two cannabinoid receptors which is an important part of endocannabinoid system, involving in a variety of physiological processes including appetite, pain-sensation, mood, and memory. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX480 | NativeExtract™ Human CNR1 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0622-KX59 | MemDX™ Recombinant Human CNR1 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPX3600K | MemDX™ Membrane Protein Human CNR1 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| S01YF-0423-KX8 | MemDX™ Human CNR1 Membrane Protein in Membrane Nanoparticles (MNP), Full Length | HEK293 cells | Full length | N/A |
| MP0253X | MemDX™ Membrane Protein Human CNR1 (Cannabinoid receptor 1) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0252X | MemDX™ Membrane Protein Human CNR1 (Cannabinoid receptor 1) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
F***x: NativeExtract™ Human CNR1 Membrane Protein (Full length, Super Nanodisc)
We purchased the NativeExtract™ Human CNR1 Membrane Protein from Creative Biolabs for our cannabinoid receptor studies, and the product exceeded our expectations.
25/Sep/2023
V***et: The customer service team was very responsive to our inquiries. Highly recommended for researchers working on GPCR-related projects!
11/Feb/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
Lentivirus-Mediated Gene Knockdown
Creative Biolabs offers lentivirus-mediated gene knockdown services. The application of lentiviral constructs, specifically those engineered for the targeted suppression of CNR1 gene expression, facilitates efficacious cellular transfection. In a notable instance, within the investigative framework of endometrial cancer, such CNR1-knockdown lentiviruses were systematically introduced into progesterone-resistant cells. Subsequent rigorous assessment of these transfected cells revealed a discernible attenuation in their proliferative dynamism and migratory potential. Concomitantly, a significant amelioration in their responsiveness to progesterone was observed, thereby underscoring the potential utility of this genetic intervention. This perhaps indicates a pivotal role for CNR1 in mediating cellular processes critical to endometrial cancer pathology and its therapeutic resistance.
Genotyping and SNP Analysis
Creative Biolabs offers genotyping and SNP analysis services. The elucidation of genetic variations within the CNR1 locus is routinely accomplished through meticulous genotyping procedures, specifically targeting single-nucleotide polymorphisms (SNPs). This analytical approach is fundamental to comprehending the inherent genomic diversity associated with the gene. The methodology typically entails the judicious selection of SNPs that exhibit robust pairwise linkage disequilibrium (LD), a statistical measure of non-random association between alleles at different loci. This systematic approach, therefore, significantly aids in deciphering the underlying genetic architecture of conditions potentially influenced by CNR1. Furthermore, it may, perhaps, furnish critical insights that could inform the judicious development of highly targeted therapeutic interventions.
Creative Biolabs offers comprehensive and innovative services to drive the development of CNR1 cell therapy. Please for more services.
Engineered Cells for Targeted Delivery
Creative Biolabs offers engineered cells for targeted delivery services. Genetic manipulation of human mesenchymal stem cells (hMSCs) offers a sophisticated avenue for the localized expression of therapeutic proteins, particularly those designed to engage with CNR1. For instance, a compelling demonstration involves the engineering of hMSCs to secrete tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). This secreted ligand possesses the inherent capacity to selectively trigger apoptosis in neoplastic cells that express CNR1. Consequently, this innovative approach may facilitate the precise and localized delivery of targeted therapeutic agents to specific cellular populations or discrete tissue microenvironments.
Gene-Edited Cells
Creative Biolabs offers gene-edited cell services. The advent of sophisticated gene editing technologies now enables precise manipulation of the CNR1 gene within cellular contexts, thereby facilitating the deliberate creation of cell lines possessing highly specific genetic modifications. These meticulously engineered cellular constructs subsequently serve a dual purpose. On the one hand, they represent promising candidates for advanced cell therapeutic applications, offering a potential avenue for rectifying pathological cellular functions. On the other hand, they provide invaluable in vitro models, allowing researchers to meticulously dissect the nuanced physiological roles of CNR1 and unravel the intricate molecular mechanisms underlying associated disease states.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
