Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Cannabinoid receptor 2 |
| Gene Name | CNR2 |
| Uniprot | P34972 (Human); P47936 (Mouse) |
| Synonym | CB2; CX5; CB-2; cannabinoid receptor 2 (macrophage) |
| Background | CNR2, also known as CB2, belongs to a G protein-coupled receptor from the cannabinoid receptor family, encoded by the CNR2 gene. It has seven transmembrane spanning domains, a glycosylated N-terminal and an intracellular C-terminal. Approximately 44% amino acid similarity is found in the human CNR1 and CNR2 receptors. And CNR2 receptor possesses about 360 amino acids, with a shorter than the 473-amino-acid-long CNR1 receptor. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX466 | NativeExtract™ Human CNR2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cells | Full length | Native Nanodisc |
| S01YF-0622-KX161 | MemDX™ Recombinant Human CNR2 Membrane Protein in Virus-Like Particles (MP-VLPs) | HEK293 cells | Full length | VLPs |
| MPX4075K | MemDX™ Membrane Protein Human CNR2 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| MP0255X | MemDX™ Membrane Protein Human CNR2 (Cannabinoid receptor 2) with GST-tag for Antibody Discovery | Wheat germ cell-free | Full length | N/A |
| MP0254X | MemDX™ Membrane Protein Human CNR2 (Cannabinoid receptor 1) without tag for Antibody Discovery | Wheat germ cell-free | Full length | Liposome |
| Please for more products or customization | ||||
G***e: NativeExtract™ Human CNR2 Membrane Protein (Full length, Super Nanodisc)
I recently purchased the NativeExtract™ Human CNR2 Membrane Protein from Creative Biolabs, and I must say, I am quite impressed. The product arrived on time, and the packaging was excellent.
06/Nov/2023
N**h: The technical support from Creative Biolabs was very helpful. They provided detailed information and guidance on how to use the product, which was very appreciated.
27/Apr/2024
We provide tailored solutions to meet your specific requirements. Please for more services.
mRNA Therapy
Creative Biolabs offers mRNA therapy development services. The transient expression of the CNR2 receptor within specific cellular targets can be effectively achieved through the sophisticated delivery of synthetic messenger RNA (mRNA encoding CNR2). This methodological approach, it is worth noting, presents a distinct advantage, particularly when investigating the immediate, or acute, cellular ramifications stemming from CNR2 activation across a diverse spectrum of cell lineages. It perhaps offers unparalleled temporal control, allowing for a focused examination of initial signaling cascades and downstream biological events.
Antisense Oligonucleotides (ASOs)
Creative Biolabs offers ASOs development services. ASOs can be precisely engineered to selectively modulate the transcriptional abundance of CNR2 messenger RNA. This targeted molecular strategy offers a potent means to achieve a specific downregulation of CNR2 expression. Such an approach, therefore, holds considerable promise in therapeutic contexts where elevated or dysregulated CNR2 activity proves detrimental, as, for instance, is observed in various oncological conditions. This perhaps represents a novel avenue for mitigating disease progression through the precise control of gene expression.
Creative Biolabs offers comprehensive and innovative services to drive the development of CNR2 cell therapy. Please for more services.
CNR2-Deficient T Cells
Creative Biolabs offers CNR2-deficient T cells development services. T lymphocytes lacking functional CNR2 exhibit a heightened capacity for antitumor activity when compared with their wild-type counterparts. This observation has been substantiated through in vivo investigations. Specifically, the adoptive transfer of CNR2-deficient T cells into murine models bearing established tumors resulted in a statistically significant deceleration of tumor progression. Furthermore, these treated animals demonstrated an enhancement in overall survival duration. Consequently, these compelling findings strongly suggest that the targeted modulation of CNR2 expression within T cells may represent a promising strategy to augment the therapeutic efficacy of adoptive T-cell transfer regimens.
Engineered Immune Cells
Creative Biolabs offers engineered immune cells development services. The genetic manipulation of immune cells, including but not limited to T lymphocytes and macrophages, to achieve elevated CNR2 expression offers a compelling strategy to potentiate their intrinsic anti-tumor or anti-inflammatory capabilities. This targeted cellular engineering approach, therefore, holds considerable promise for therapeutic applications. Specifically, it may prove exceptionally beneficial within the intricate landscape of cancer immunotherapy, where enhanced immune surveillance is paramount, and in the management of chronic autoimmune disorders, where the precise modulation of inflammatory responses is crucial. This technique perhaps represents a significant advancement in leveraging cellular machinery for specific therapeutic outcomes.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
