Anti-Aβ40 fibrill Aptamer(Cat#: CTMM-0124-TT5)
This product is an aptamer which binds to the Aβ40 fibrill with an affinity of 1-50 nM.
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Summary
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Specifications
| Target Category |
Protein |
| Target |
Aβ40 |
| Alternative Names |
APP; Amyloid Beta Precursor Protein; Alpha-SAPP; AD1; Alzheimer Disease Amyloid A4 Protein Homolog; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid; Peptide;Amyloid-Beta Precursor Protein; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PN-II; PreA4; ABPP; APPI; CVAP; Amyloid-Beta (A4) Precursor Protein; Beta-Amyloid Precursor Protein; Testicular Tissue Protein Li 2; Beta-Amyloid Peptide(1-40); Beta-Amyloid Peptide(1-42); Amyloid Beta A4 Protein; Beta-Amyloid Peptide; CTFgamma; ABETA; AAA; PN2; A4 |
| Gene ID |
351 |
| UniProt ID |
P05067 |
| Target Overview |
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. |
| Type |
RNA |
| Length |
100-200 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
10 mM Tris-HCl, 150 mM NaCl, 5 mM MgCl₂, 1 mM EDTA, pH 7.5 |
| GC Content |
55.06% |
| Molecular Weight |
27067.06 g/mole |
| nmoles/OD260 |
1.26 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
