Anti-AIFM1 Aptamer(Cat#: CTApt-1094)
This product is an aptamer which binds to the AIFM1 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
AIFM1 |
| Alternative Names |
Apoptosis Inducing Factor Mitochondria Associated 1; AIF; Apoptosis-Inducing Factor, Mitochondrion-Associated, 1; Programmed Cell Death 8 (Apoptosis-Inducing Factor) ; Apoptosis-Inducing Factor 1, Mitochondrial; Auditory Neuropathy, X-Linked Recessive 1; CMTX4; DFNX5; PDCD8; Neuropathy, Axonal, Motor-Sensory With Deafness And Mental Retardation (Cowchock Syndrome) ; Apoptosis Inducing Factor, Mitochondria Associated 1; Striatal Apoptosis-Inducing Factor; Testicular Secretory Protein Li 4; Programmed Cell Death Protein 8; EC 1.6.99.- ; COXPD6; SEMDHL; AUNX1; CMT2D; COWCK; NADMR; NAMSD; AIFM1; |
| Gene ID |
9131 |
| UniProt ID |
O95831 |
| Target Overview |
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
