This is an aptamer development services to screening aptamers binds to the ARHGEF25 with an affinity of 1nM~1μM.
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| Target Category | Protein |
| Target | ARHGEF25 |
| Alternative Names | Rho Guanine Nucleotide Exchange Factor 25; P63RhoGEF; GEFT; RhoA/Rac/Cdc42 Guanine Nucleotide Exchange Factor GEFT; Rho Guanine Nucleotide Exchange Factor (GEF) 25; Guanine Nucleotide Exchange Factor GEFT; Rac/Cdc42/Rho Exchange Factor GEFT; RAC/CDC42 Exchange Factor; RhoA/RAC/CDC42 Exchange Factor; ARHGEF25 |
| Gene ID | 115557 |
| UniProt ID | Q86VW2 |
| Target Overview | Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Chemical Modification | N/A |
| Type | DNA |
| Length | 20-80 nt |
| Affinity (Kd) | 1nM~1μM |
| Binding Conditions/Buffer | PBS; buffer system with Serum; other |