Anti-CDKN2A Aptamer SELEX Service(Cat#: CTApt-809)
This is an aptamer development services to screening aptamers binds to the CDKN2A with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
CDKN2A |
| Alternative Names |
Cyclin Dependent Kinase Inhibitor 2A; P14ARF; CDK4I; MTS1; ARF; Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4); Cyclin-Dependent Kinase 4 Inhibitor A; Cyclin-Dependent Kinase Inhibitor 2A; Multiple Tumor Suppressor; Alternative Reading Frame; P16INK4A; CDKN2; MTS-1; CMM2; INK4 2; MLM 3; P14 2; P16 2; P19 2; Cell Cycle Negative Regulator Beta; CDK4 Inhibitor P16-INK4; Tumor Suppressor ARF; P16-INK4A; P16-INK4a; P16INK4a; P16-INK4; P16INK4; P19ARF; CDKN2A; P19Arf; INK4A; INK4a; TP16 |
| Gene ID |
1029 |
| UniProt ID |
P42771 |
| Target Overview |
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 pro |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
