Anti-EpCAM Aptamer (RNA aptamer)(Cat#: CTApt-M-1940)
This product is an aptamer which binds to the EpCAM with an affinity of <100 nM.
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Summary
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Specifications
| Target Category |
Protein |
| Target |
EpCAM |
| Alternative Names |
Epithelial Cell Adhesion Molecule; TROP1; KSA; Tumor-Associated Calcium Signal Transducer 1; GA733-2; TACSTD1; Ep-CAM; EGP40; EGP-2; KS1/4; MIC18; MK-1; M4S1; ESA; Major Gastrointestinal Tumor-Associated Protein GA733-2; Trophoblast Cell Surface Antigen 1; Adenocarcinoma-Associated Antigen; Cell Surface Glycoprotein Trop-1; Epithelial Glycoprotein 314; TACST-1; HEA125; 323/A3; CO-17A; EGP314; EGP34; CD326; MOC31; 17-1A; Ly74; MH99; Membrane Component, Chromosome 4, Surface Marker (35kD Glycoprotein) ; Antigen Identified By Monoclonal Antibody AUA1; Human Epithelial Glycoprotein-2; Epithelial Cell Surface Antigen; Epithelial Glycoprotein; KS 1/4 Antigen; CD326 Antigen; HEGP314; HNPCC8; DIAR5; M1S2; EGP |
| Gene ID |
4072 |
| UniProt ID |
P16422 |
| Target Overview |
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. |
| Chemical Modification |
2'-F-RNA |
| Length |
20-40 nt |
| Affinity (Kd) |
<100 nM |
| Binding Conditions/Buffer |
Assay Buffer: DPBS with 5 mM MgCl2, 0.1 mg/ml tRNA, 0.1 mg/ml salmon sperm DNA, 02% [w/v] sodium azide, and 5% FCS. The final concentration of MgCl2 was 2.5 mM. |
| GC Content |
0.6842 |
| Molecular Weight |
6392.85 g/mole |
| Extinction Coefficient |
188200 L/(mole·cm) |
| nmoles/OD260 |
5.31 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
