Anti-Human BCL2L1 Aptamer(Cat#: CTMM-0124-RJ64)

This product is an aptamer which binds to Human BCL2L1 with a high affinity.

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Specifications
Target Category Protein
Target BCL2L1
Alternative Names BCL2 Like 1; BCL2L; BCLX; PPP1R52; Protein Phosphatase 1, Regulatory Subunit 52; Apoptosis Regulator Bcl-X; Bcl-2-Like Protein 1; Bcl-X; BCL-XL/S; Bcl2-L-1; Bcl-XL; Bcl-XS; BCL-XL; BCL-XS; BCL-X; BCL2L1
Gene ID 598
UniProt ID Q07817
Target Overview The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
Type Peptide
Species Reactivity Human
Length <50 nt
Binding Conditions/Buffer PBS
Molecular Weight 627.8 g/mole

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