Anti-Human C5 Aptamer(Cat#: CTWZ-0124-WZ16)
This product is an aptamer which binds to human C5 with an affinity of 1-50 nM.
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Summary
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Specifications
| Target Category |
Protein |
| Target |
C5 |
| Alternative Names |
Complement C5; CPAMD4; C3 And PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4; Complement Component 5; C5a Anaphylatoxin; Prepro-C5; C5a; C5b; Anaphylatoxin C5a Analog; ECLZB; C5D; C5A; C5B |
| Gene ID |
727 |
| UniProt ID |
P01031 |
| Target Overview |
This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
PBS with 1 mM MgCl2 (MgPBS) |
| GC Content |
46.88% |
| Molecular Weight |
9040.7 g/mole |
| nmoles/OD260 |
3.184 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
