This product is an unconjugated anti-Mouse CD11c Monoclonal antibody (CTJS-351) generated from the Armenian Hamster. The antibody can be used for FC; IF; IHC; IP.
Clonality | Monoclonal |
Clone | CTJS-351 |
Host Animal | Armenian Hamster |
Isotype | IgG |
Immunogen | Mouse CD11c+ T Cells |
Species Reactivity | Mouse |
Applications | FC; IF; IHC; IP |
Application Notes | FC: 1:10-1:1000 IF: 1:10-1:500 IHC: 1:10-1:500 IP: 1:10-1:500 The optimal working dilutions should be determined by the end user. |
Specificity | This antibody reacts with mouse CD11c dendritic cells, NK cells, intestinal intraepithelial lymphocytes (IEL), and some activated T cells. |
Purity | ≥95% as determined by SDS-PAGE |
Format | Liquid |
Size | 100; 500 µg |
Storage | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
Type | Primary Antibody |
Target Name | CD11c |
Alternative Names | Integrin Subunit Alpha X; Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit); Complement Component 3 Receptor 4 Subunit; Integrin Alpha-X; CD11C; Integrin Alpha X; CD11c Antigen; ITGAX; CD11c |
Gene ID | 3687 |
UniProt ID | P20702 |
Introduction | CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias. |