Bovine Complement C5 ELISA Kit(Cat#: CTK-315)
This product is an ELISA kit for the determination of Bovine Complement C5 in the samples of Serum, Plasma, Tissue Homogenate. It is highly sensitive and available for the detection of Guinea pig Complement C5 as low as 0.156 ng/mL.
Summary
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Specifications
| Assay Type |
Sandwich ELISA |
| Sensitivity |
0.156 ng/mL (0.625-40 ng/mL) |
| Pack Size |
96 tests |
| Species Reactivity |
Bovine |
| Target |
C5 |
| Cross Reactivity |
No significant cross-reactions have been observed between Bovine Complement C5 and analogues, but existing techniques may limit the detection of cross-reactions with untested analogues. |
| Applications |
ELISA |
| Storage |
Short-term storage at 4°C and long-term storage at -20°C. |
Information
| Introduction |
Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. C5 is composed of alpha (C5a) and beta (C5b) polypeptide chains. Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
