Cow CD18 ELISA Kit(Cat#: CTK-863)
This product is an ELISA kit for the in vitro determination of Cow CD18 in the samples of Tissue homogenates, cell lysates and other biological fluids. It is highly sensitive and available for the detection of Cow CD18 as low as 0.156 ng/mL.
Summary
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Specifications
| Assay Type |
Sandwich ELISA |
| Sensitivity |
0.156-10 ng/mL |
| Species Reactivity |
Cow |
| Target |
CD18 |
| Cross Reactivity |
No significant cross-reactions have been observed between Cow CD18 and analogues, but existing techniques may limit the detection of cross-reactions with untested analogues. |
| Applications |
ELISA |
| Storage |
Short-term storage at 4°C and long-term storage at -20°C. |
Information
| Introduction |
CD18 (Integrin ITGAL/ITGB2) is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
