This product is an Anti-Human C4 Polyclonal Antiserum from goats immunized with highly purified human C4 protein. It is not a purified IgG fraction.
Host Animal | Goats |
Isotype | IgG |
Immunogen | C4 protein |
Applications | Western Blots; ELISA; Immunodiffusion |
Application Notes | Immunodiffusion: 1/8; WB: 1/128,000; ELISA: 1/256,000 |
Specificity | C4 |
Format | Frozen liquid |
Size | 1ml |
Storage | Store at 4°C short term. Store at -20°C or below long term. Avoid freeze-thaw cycles. |
Target Name | C4 |
Alternative Names | Complement C4; Complement Component C4; Complement Component 4 ; C4 |
Gene ID | 720 |
UniProt ID | P0C0L4 |
Introduction | Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |