This product is an anti-Human CD59 Polyclonal antibody generated from the Goat. The antibody can be used for WB; ELISA; IHC.
Clonality | Polyclonal |
Host Animal | Goat |
Isotype | IgG |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human CD59 Leu26-Asn102 |
Species Reactivity | Human |
Applications | WB; ELISA; IHC |
Application Notes | WB: 1 µg/mL IHC: 5-15 µg/mL The optimal working dilutions should be determined by the end user. |
Specificity | This antibody reacts with Human CD59. |
Purity | ≥95% as determined by SDS-PAGE |
Format | Lyophilized |
Size | 25; 100 µg |
Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Type | Primary Antibody |
Target Name | CD59 |
Alternative Names | T cell-activating protein; 16.3A5; 1F5 antigen; 1F5; 20 kDa homologous restriction factor; CD59 antigen p18-20 (antigen identified by; monoclonal antibodies 16.3A5; EJ16; CD59 antigen; CD59 antigen; complement regulatory protein; CD59 glycoprotein; CD59 molecule; complement regulatory protein; CD59; EJ16; EJ30; EJ30; EL32 and G344); EL32; FLJ38134; FLJ92039; G344; HRF20; HRF-20; human leukocyte antigen MIC11; Ly-6-like protein; lymphocytic antigen CD59/MEM43; MACIF; MAC-inhibitory protein; MAC-IP; MEM43 antigen; MEM43; membrane attack complex (MAC) inhibition factor; Membrane attack complex inhibition factor; Membrane inhibitor of reactive lysis; MGC2354; MIC11; MIC11MSK21; MIN1; MIN2; MIN3; MIRL; p18-20; Protectin; surface anitgen recognized by monoclonal 16.3A5 |
Gene ID | 966 |
UniProt ID | P13987 |
Introduction | CD59 glycoprotein, also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a protein that in humans is encoded by the CD59 gene. It belongs to the LY6/uPAR/alpha-neurotoxin protein family. CD59 attaches to host cells via a glycophosphatidylinositol (GPI) anchor. When complement activation leads to deposition of C5b678 on host cells, CD59 can prevent C9 from polymerizing and forming the complement membrane attack complex. It may also signal the cell to perform active measures such as endocytosis of the CD59-CD9 complex. Mutations affecting GPI that reduce expression of CD59 and decay-accelerating factor on red blood cells result in paroxysmal nocturnal hemoglobinuria. Viruses such as HIV, human cytomegalovirus and vaccinia incorporate host cell CD59 into their own viral envelope to prevent lysis by complement. |