Human Complement C1QBP ELISA Kit-CTK-034(Cat#: CTK-034)
This product is an ELISA kit for the determination of Human Complement C1QBP in the samples of Cell Culture Supernatant, Plasma, Serum, Tissue Homogenate. It is highly sensitive and available for the detection of Human Complement C1QBP as low as 1 pg/mL.
Summary
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Specifications
| Assay Type |
Sandwich ELISA |
| Sensitivity |
1.0 pg/mL (250-5000 pg/mL) |
| Pack Size |
96 tests |
| Species Reactivity |
Human |
| Target |
C1QBP |
| Applications |
ELISA |
| Storage |
4°C |
Information
| Introduction |
C1QBP is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. It acts as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades at the cell surface. It is a putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. It is a high affinity receptor for kininogen-1/HMWK in complex with cytokeratin-1/KRT1. The secreted form of C1qBP may enhance both extrinsic and intrinsic coagulation pathways. It also involves in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection; HIV-1 replication, presumably by contributing to splicing of viral RNA; infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B and Staphylococcus aureus protein A; and replication of Rubella virus. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
