Human Complement C4A des Arg ELISA Kit(Cat#: CTK-227)
This product is an ELISA kit for the determination of Human Complement C4A des Arg in the samples of serum, plasma or cell culture medium. It is highly sensitive and available for the detection of Human Complement C4A as low as 0.76 ng/mL.
Summary
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Specifications
| Assay Type |
Sandwich ELISA |
| Sensitivity |
0.76 ng/mL (0.78-200 ng/mL) |
| Pack Size |
96 tests |
| Species Reactivity |
Human |
| Target |
C4a |
| Cross Reactivity |
C4a des Arg (100%), C4 (2.14%), C5a des Arg (0.28%), C3 (0.23%), C3a des Arg (0.04%), C5 (0.02%) |
| Applications |
ELISA |
| Storage |
4°C |
Information
| Introduction |
Complement C4A is a non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
