Human Complement iC3b ELISA Kit (wide range)(Cat#: CTK-921)

Name: Human Complement iC3b ELISA Kit (wide range)
SKU: CTK-921
Rating: 5 (1 reviews)

This product is an ELISA kit for the in vitro determination of Human iC3b in the samples of Plasma, Serum. It is highly sensitive and available for the detection of Human iC3b as low as 18.75 ng/mL.

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Specifications

Assay Type	Sandwich ELISA
Sensitivity	18.75 ng/mL (31.25-2000 ng/mL)
Species Reactivity	Human
Target	iC3b
Cross Reactivity	No significant cross-reactions have been observed between Human iC3b and analogues, but existing techniques may limit the detection of cross-reactions with untested analogues.
Applications	ELISA
Storage	Short-term storage at 4°C and long-term storage at -20°C.

Information

Introduction

Complement iC3b is an inactive form of C3b, which is formed through the cleavage of C3b by factor I in the presence of factor H. Complement receptors on white blood cells are able to bind iC3b, so iC3b functions as an opsonin. Unlike intact C3b, iC3b cannot associate with factor B, thus preventing amplification of the complement cascade through the alternative pathway. Complement factor I can further cleave iC3b into a protein fragment known as C3d.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.