As a leading service biotech company, Creative Biolabs has armed with a powerful and standardized in vivo analysis platform, aiming to offer the best and convenient aptamer related services. We are dedicated to timely, high-quality service from the start of your project to the finish.
Aptamers are synthetic single-stranded DNA or RNA molecules selected to bind to targets of diverse nature. In a manner analogous to the function of antibodies, the spatial structure of aptamers can identify and bind to unique ligand ranging from a small organic molecule to a whole cell with high specificity and affinity.
Aptamer In Vivo Analysis
In vivo study of aptamers is a fruitful field of scientific research. Ideally, for in vivo applications, aptamers should be selected in a in vivo-like system or, ultimately, in a whole in vivo organism. Also, the challenge in identifying aptamers with optimal in vivo specificity and the nature of their pharmacokinetics can be achieved by in vivo analysis to ensure their therapeutic success in vivo, and subsequently in the clinic. In particular, the careful in vitro study of aptamers coupled with in vivo analyses would reveal many workings of the aptamer system in the living cell context.
Fig.1 Aptamer in vivo application. (Wiraja, 2014)
In Vivo Analysis Services for Aptamer Development
Creative Biolabs is a dedicated in vivo analysis provider that strives to provide the highest quality service. Our experts can develop and carry out in vivo analysis tailored specifically for your projects. We have more than 20 years of experience in generating, characterizing, and maintaining animal models and applying them for aptamer in vivo testing projects. Moreover, we offer access to individual animal models and our in vivo analysis platform as contract research or on a collaborative research basis. To meet your specific aptamer development project's needs, we develop custom in vivo models and select the most appropriate platform, in vivo study design, and analysis method tailored to your goals. By partnering with Creative Biolabs, you are gaining access to in vivo support services that increase the potential for your research to be successful.
Advantages of our In Vivo Analysis Services
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Transition seamlessly from in vitro to in vivo studies
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Rapidly screening single or combination aptamers in vivo
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Cost-effective evaluation of in vivo aptamer efficacy in well-established models
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Investigating potential aptamer toxicities with in vivo models
An independent laboratory combining state-of-the-art technology with personal service and attention, Creative Biolabs provide services to meet all your quality needs. We are currently proud to offers aptamer in vivo analysis service for our customers all over the world. Please contact us a note or give us a call to find out what Creative Biolabs can do for you.
Reference
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Wiraja, C.; et al. Aptamer technology for tracking cells’ status & function. Molecular and cellular therapies. 2014. 2(1), pp.1-14.
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Questions & Answer
A: Animal models like mice, rats, and non-human primates are often used due to their genetic similarity to humans. The choice of model depends on the specific research objectives and the aptamer's intended therapeutic application.
A: Our researchers will adhere to regulatory guidelines and ethical standards when conducting in vivo studies. Compliance with Good Laboratory Practices (GLP) and relevant animal welfare regulations is essential for the successful translation of aptamer research into clinical applications.
A: The pharmacokinetics of aptamers are assessed by monitoring the absorption, distribution, metabolism, and excretion of the aptamer in the organism. Creative Biolabs generally provides this information through blood and tissue sampling and analytical techniques.
For Research Use Only.
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