This product is an unconjugated anti-Bovine Vitronectin Monoclonal antibody (CTJS-229) generated from the Mouse. The antibody can be used for ELISA; IHC.
Clonality | Monoclonal |
Clone | CTJS-229 |
Host Animal | Mouse |
Isotype | IgG1 Kappa |
Immunogen | Lysed bovine corneal endothelial cells and extracellular matrix |
Species Reactivity | Bovine; Equine; Rabbit |
Applications | ELISA; IHC |
Application Notes | ELISA: 1:100-1:2000 IHC: 1:10-1:500 The optimal working dilutions should be determined by the end user. |
Specificity | This antibody reacts with Bovine, Equine, Rabbit Vitronectin. |
Purity | ≥95% as determined by SDS-PAGE |
Format | Liquid |
Size | 50; 250 µg |
Storage | Store at 4°C. Do not freeze. |
Type | Primary Antibody |
Target Name | Vitronectin |
Alternative Names | Serum Spreading Factor; Complement S-Protein; Somatomedin B; S-Protein; V75; VN; Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein); Serum-Spreading Factor; Epibolin; VNT |
Gene ID | 7448 |
UniProt ID | P04004 |
Introduction | Vitronectin (VTN or VN) is a glycoprotein of the hemopexin family which is abundantly found in serum, the extracellular matrix and bone.In humans it is encoded by the VTN gene. Vitronectin binds to integrin alpha-V beta-3 and thus promotes cell adhesion and spreading. It also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpins (serine protease inhibitors). It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. Vitronectin has been speculated to be involved in hemostasis and tumor malignancy. |