Mouse Anti-Human C4 Monoclonal Antibody (CTJS-326)(Cat#: CTA-1160)
This product is an unconjugated anti-Human Complement C4 Monoclonal antibody (CTJS-326) generated from the Mouse. The antibody can be used for ELISA.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-326 |
| Host Animal |
Mouse |
| Isotype |
IgG1 |
| Immunogen |
C4 purified from Human blood |
| Species Reactivity |
Human |
| Applications |
ELISA |
| Application Notes |
ELISA: 1 µg/mL
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human Complement C4. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
Unconjugated |
| Format |
Liquid |
| Size |
100 μg |
| Storage |
Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle. |
| Type |
Primary Antibody |
Target
| Target Name |
C4 |
| Alternative Names |
Complement C4; Complement Component C4; Complement Component 4 ; C4 |
| Gene ID |
720 |
| UniProt ID |
P0C0L4 |
Information
| Introduction |
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
