Mouse Anti-Human CD18 Monoclonal Antibody (CTJS-284) [HRP](Cat#: CTA-894)

Name: Mouse Anti-Human CD18 Monoclonal Antibody (CTJS-284) [HRP]
SKU: CTA-894
Rating: 5 (1 reviews)

This product is a conjugated anti-Human CD18 Monoclonal antibody (CTJS-284) generated from the Mouse. The antibody can be used for WB, IHC, ELISA.

INQUIRY

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number

TOP

Summary Related Products & Services

Specifications

Clonality	Monoclonal
Clone	CTJS-284
Host Animal	Mouse
Isotype	IgG2a κ
Immunogen	The full length of human Integrin β2, a.a. 1-769
Species Reactivity	Human
Applications	WB; IHC; ELISA
Application Notes	WB: 1:100-1:1000 IHC: 1:50-1:500 ELISA: 1:30-1:3000 The optimal working dilutions should be determined by the end user.
Specificity	This antibody reacts with Human CD18.
Purity	≥95% as determined by SDS-PAGE
Conjugation	HRP
Format	Liquid
Size	200 µg
Storage	Store in dark at 4°C. Do Not Freeze.
Type	Primary Antibody

Target

Target Name	CD18
Alternative Names	Integrin Subunit Beta 2; Integrin, Beta 2 (Complement Component 3 Receptor 3 And 4 Subunit); Complement Component 3 Receptor 3 And 4 Subunit; Integrin Beta-2; LFA-1; MAC-1; CD18; Complement Receptor C3 Beta-Subunit; Complement Receptor C3 Subunit Beta; Integrin Beta Chain, Beta 2; CD18 Antigen; ITGB2
Gene ID	3689
UniProt ID	P05107

Information

Introduction

Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.