Mouse Anti-Human CD18 Monoclonal Antibody (CTJS-110)(Cat#: CTA-885)
This product is an unconjugated anti-Human CD18 Monoclonal antibody (CTJS-110) generated from the Mouse. The antibody can be used for FC, IA, ICC, IF, Neut, IHC.
Summary
Related Products & Services
Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-110 |
| Host Animal |
Mouse |
| Isotype |
IgG1 |
| Immunogen |
Human Beta 2 Integrin |
| Species Reactivity |
Human; Mouse; Hamster |
| Applications |
FC; IA; ICC; IF; Neut; IHC |
| Application Notes |
FC: 0.5 µg/10^6 cells
ICC: 1:10-1:100
IF: 1:10-1:100
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human, Mouse, and Hamster CD18. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
Unconjugated |
| Format |
Liquid |
| Size |
200 µg |
| Storage |
Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle. |
| Type |
Primary Antibody |
| ProAb |
NeutAb |
Target
| Target Name |
CD18 |
| Alternative Names |
Integrin Subunit Beta 2; Integrin, Beta 2 (Complement Component 3 Receptor 3 And 4 Subunit); Complement Component 3 Receptor 3 And 4 Subunit; Integrin Beta-2; LFA-1; MAC-1; CD18; Complement Receptor C3 Beta-Subunit; Complement Receptor C3 Subunit Beta; Integrin Beta Chain, Beta 2; CD18 Antigen; ITGB2 |
| Gene ID |
3689 |
| UniProt ID |
P05107 |
Information
| Introduction |
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
