Mouse Anti-Human CFHR4 Monoclonal Antibody (CTJS-442)(Cat#: CTA-054)
This product is an unconjugated anti-Human CFHR4 Monoclonal antibody (CTJS-442) generated from the Mouse. The antibody can be used for WB; FC; ICC.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-442 |
| Host Animal |
Mouse |
| Isotype |
IgG1 |
| Immunogen |
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Complement Factor H-related 4/CFHR4
Glu20-Glu331 |
| Species Reactivity |
Human |
| Applications |
WB; FC; ICC |
| Application Notes |
WB: 2 µg/mL
ICC: 8-25 µg/mL
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human CFHR4. |
| Purity |
≥95% as determined by SDS-PAGE |
| Format |
Lyophilized |
| Size |
25; 100 µg |
| Storage |
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Type |
Primary Antibody |
Target
| Target Name |
CFHR4 |
| Alternative Names |
Complement Factor H Related 4; FHR-4; FHR4; Complement Factor H-Related Protein 4; Complement Factor H-Related 4 |
| Gene ID |
10877 |
| UniProt ID |
Q92496 |
Information
| Introduction |
FHR4 (Complement factor H-related protein 4; also FHR4B and CFHR4) is a 45 kDa glycoprotein member of the factor H-related protein family. It is synthesized by hepatocytes and circulates in plasma. FHR4(B) binds to C3b and C3d. It also binds to native (pentameric) C-reactive protein (pCRP), and is suggested to promote pCRP binding to necrotic cells surfaces, thus promoting cell clearance. Mature human CFHR is 312 amino acids (aa) in length. It contains five Sushi/SCR domains, the first of which (aa 23-85) is associated with pCRP binding. There is a circulating, 86 kDa alternative splice form termed FHR4A that shows an insertion of 247 aa after Asp92. This is considered the dominant isoform, and appears to show the same activity as CFHR. Over aa 41-331, human CFHR shares 61% aa identity with a related molecule found in rat. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
