Mouse Anti-Human CFHR5 Monoclonal Antibody (CTJS-159)(Cat#: CTA-167)
This product is an unconjugated anti-Human CFHR5 Monoclonal antibody (CTJS-159) generated from the Mouse. The antibody can be used for WB; ELISA; FC; IF; IHC.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-159 |
| Host Animal |
Mouse |
| Isotype |
IgG2a |
| Immunogen |
Purified recombinant fragment of human CFHR5 (AA: 344-569) expressed in E. Coli. |
| Species Reactivity |
Human |
| Applications |
WB; ELISA; FC; IF; IHC |
| Application Notes |
WB: 1:500-1:2000
ELISA: 1:10000
FC: 1:200-1:400
IF: 1:200-1:1000
IHC: 1:200-1:1000
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human CFHR5. |
| Purity |
≥95% as determined by SDS-PAGE |
| Format |
Liquid |
| Size |
25; 100 µg |
| Storage |
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Type |
Primary Antibody |
Target
| Target Name |
CFHR5 |
| Alternative Names |
Complement Factor H Related 5; CFHL5; FHR-5; FHR5; Complement Factor H-Related Protein 5; Complement Factor H-Related 5; Factor H-Related Protein 5; Factor H Related Protein 5; CFHR5D |
| Gene ID |
81494 |
| UniProt ID |
Q9BXR6 |
Information
| Introduction |
Complement factor H-related protein 5 is a protein that in humans is encoded by the CFHR5 gene. CFHR5 is structurally related to complement factor H which plays an important role in the regulation of a branch of the innate immune system called the alternative complement pathway. Like complement factor H, CFHR5 is able to bind to complement C3. A mutation in CHFR5 was found in patients with the disease CFHR5 nephropathy, which is a common cause of renal disease in Cyprus. The mutated form of the protein found in patients with this disease has impaired ability to bind to complement C3, suggesting that CFHR5 is important in protecting the kidneys from attack by the complement system. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
