This product is an unconjugated anti-Human CR1 Monoclonal antibody (CTJS-321) generated from the Mouse. The antibody can be used for FC; ELISA.
Clonality | Monoclonal |
Clone | CTJS-321 |
Host Animal | Mouse |
Isotype | IgG1 |
Immunogen | Mouse myeloma cell line NS0-derived recombinant human CD35 Gln42-Asp1971 (His1208Arg) |
Species Reactivity | Human |
Applications | FC; ELISA |
Application Notes | FC: 2.5 ug/10^6 cells The optimal working dilutions should be determined by the end user. |
Specificity | This antibody reacts with Human CR1. |
Purity | ≥95% as determined by SDS-PAGE |
Format | Lyophilized |
Size | 25; 100 µg |
Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Type | Primary Antibody |
Target Name | CR1 |
Alternative Names | Complement C3b/C4b Receptor 1 (Knops Blood Group); C3b/C4b Receptor; CD35 Antigen; Knops Blood Group Antigen; Complement Receptor 1; C3-Binding Protein; Complement Receptor Type 1; KN; C3BR; C4BR; CD35; Cr1; C3DR; CD21; Cr-1; Cr-2 |
Gene ID | 1378 |
UniProt ID | P17927 |
Introduction | Complement receptor 1 (CR1) also known as CD35, cluster of differentiation 35, is a protein that in humans is encoded by the CR1 gene. CR1 can act as a negative regulator of the complement cascade, mediate immune adherence and phagocytosis and inhibit both the classic and alternative pathways. Complement receptor 2 (CR2), also known as CD21, cluster of differentiation 21, is a protein that in humans is encoded by the CR2 gene. CR2 is involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d. B cells have CR2 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation. |