Mouse Anti-Human CR3 Monoclonal Antibody (CB-CT042)(Cat#: CTA-908)
This product is an unconjugated anti-Human CR3 Monoclonal antibody (CB-CT042) generated from the Mouse. The antibody can be used for DB, FC, IHC, Inhib.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-693 |
| Host Animal |
Mouse |
| Isotype |
IgG1 |
| Epitope |
The A domain of CD11b |
| Immunogen |
Recombinant human CD11b tagged with GST corresponding to 211 amino acids of the A-domain |
| Species Reactivity |
Human; Primate |
| Applications |
DB; FC; IHC; Inhib |
| Application Notes |
FC: 1 µg/10^6 cells
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody detects CD11b/CD18 in human neutrophils. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
Unconjugated |
| Format |
Liquid |
| Size |
25 µg |
| Storage |
Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle. |
| Type |
Primary Antibody |
Target
| Target Name |
CR3 |
| Alternative Names |
Complement receptor 3; CR3; Macrophage-1 antigen; integrin αMβ2; macrophage integrin; Mac-1; CD11b/CD18 |
| Gene ID |
3684
3689 |
| UniProt ID |
P11215
P05107 |
Information
| Introduction |
Complement receptor 3, also known as Macrophage-1 antigen, integrin αMβ2 or macrophage integrin or Mac-1, is a a human cell surface receptor consisting of CD11b (integrin αM) and CD18 (integrin β2). It is mainly expressed B and T lymphocytes, polymorphonuclear leukocytes (mostly neutrophils), NK cells, and mononuclear phagocytes like macrophages. CR3 is a pattern recognition receptor, capable of recognizing and binding to many molecules found on the surfaces of invading bacteria. CR3 also recognizes iC3b when bound to the surface of foreign cells. iC3b is generated by proteolysis of C3b and binding to the receptor causes phagocytosis and destruction of the foreign cell opsonized with iC3b. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
