Mouse Anti-Human Factor H Monoclonal Antibody (CTJS-161) [Biotin](Cat#: CTA-622)
This product is a conjugated anti-Human Complement Factor H Monoclonal antibody (CTJS-161) generated from the Mouse. The antibody can be used for ELISA.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-161 |
| Host Animal |
Mouse |
| Isotype |
IgG1 κ |
| Immunogen |
Human complement Factor H |
| Species Reactivity |
Human |
| Applications |
ELISA |
| Application Notes |
ELISA: 1:16000
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human Complement Factor H. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
Biotin |
| Format |
Liquid |
| Size |
100 µL |
| Storage |
Store in dark at 4°C. Do Not Freeze. |
| Type |
Primary Antibody |
Target
| Target Name |
Factor H |
| Alternative Names |
Complement Factor H; Age-Related Maculopathy Susceptibility 1; H Factor (Complement); Beta-1H; FHL1 ; Adrenomedullin Binding Protein; Beta-1-H-Globulin; H Factor; Factor H; CFH; FH |
| Gene ID |
3075 |
| UniProt ID |
P08603 |
Information
| Introduction |
Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
