This product is a HRP conjugated anti-Human Complement MASP-1 Monoclonal antibody (TJL-208) generated from the Mouse. The antibody can be used for WB, IHC, ELISA.
Clonality | Monoclonal |
Clone | TJL-208 |
Host Animal | Mouse |
Isotype | IgG2b |
Immunogen | Human MASP-1, a.a. 171-430 |
Species Reactivity | Human |
Applications | WB; IHC; ELISA |
Application Notes | WB: 1:100-1:1000 IHC: 1:50-1:500 ELISA: 1:30-1:3000 The optimal working dilutions should be determined by the end user. |
Specificity | This antibody reacts with Human Complement MASP-1. |
Purity | ≥95% as determined by SDS-PAGE |
Conjugation | HRP |
Format | Liquid |
Size | 200 µg |
Storage | Store in dark at 4°C. Do Not Freeze. |
Type | Primary Antibody |
Target Name | MASP1 |
Alternative Names | Complement Factor MASP3; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; CRARF1; CRARFMAP1; DKFZp686I01199; EC 3.4.21; EC 3.4.21.-; EC 3.4.21.104; EC 3.4.21.42; FLJ26383; mannan-binding lectin serine peptidase 1 (C4/C2 activating component ofRa-reactive factor); mannan-binding lectin serine protease 1 (C4/C2 activating component ofRa-reactive factor); mannan-binding lectin serine protease 1; Mannose-binding lectin-associated serine protease 1; Mannose-binding protein-associated serine protease; MAp44; MASP; MASP1; MASP-1; MASP3; MGC126283; MGC126284; PRSS5; Ra-reactive factor serine protease p100; RaRF; Serine protease 5 |
Gene ID | 5648 |
UniProt ID | P48740 |
Introduction | Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene. MASP-1 is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 to form C4b2a, a C3-convertase. MASP-1 is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. MASP-1 is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. MASP-1 is also able to cleave fibrinogen and factor XIII and may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. |