Mouse Anti-Human MASP-1 Monoclonal Antibody (TJL-208) [iFluor® 546](Cat#: CTMM-0322-JL2229)

Name: Mouse Anti-Human MASP-1 Monoclonal Antibody (TJL-208) [iFluor® 546]
SKU: CTMM-0322-JL2229
Rating: 5 (1 reviews)

This product is an iFluor® 546 conjugated anti-Human Complement MASP-1 Monoclonal antibody (TJL-208) generated from the Mouse. The antibody can be used for WB, IF, IHC, FCM.

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Specifications

Clonality	Monoclonal
Clone	TJL-208
Host Animal	Mouse
Isotype	IgG2b
Immunogen	Human MASP-1, a.a. 171-430
Species Reactivity	Human
Applications	WB; IF; IHC; FCM
Application Notes	WB: 1:100-1:1000 IF: 1:50-1:500 IHC: 1:50-1:500 The optimal working dilutions should be determined by the end user.
Specificity	This antibody reacts with Human Complement MASP-1.
Purity	≥95% as determined by SDS-PAGE
Conjugation	iFluor® 546
Format	Liquid
Size	200 µg
Storage	Store in dark at 4°C. Do Not Freeze.
Type	Primary Antibody

Target

Target Name	MASP1
Alternative Names	Complement Factor MASP3; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; CRARF1; CRARFMAP1; DKFZp686I01199; EC 3.4.21; EC 3.4.21.-; EC 3.4.21.104; EC 3.4.21.42; FLJ26383; mannan-binding lectin serine peptidase 1 (C4/C2 activating component ofRa-reactive factor); mannan-binding lectin serine protease 1 (C4/C2 activating component ofRa-reactive factor); mannan-binding lectin serine protease 1; Mannose-binding lectin-associated serine protease 1; Mannose-binding protein-associated serine protease; MAp44; MASP; MASP1; MASP-1; MASP3; MGC126283; MGC126284; PRSS5; Ra-reactive factor serine protease p100; RaRF; Serine protease 5
Gene ID	5648
UniProt ID	P48740

Information

Introduction

Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene. MASP-1 is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 to form C4b2a, a C3-convertase. MASP-1 is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. MASP-1 is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. MASP-1 is also able to cleave fibrinogen and factor XIII and may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.