Mouse Anti-Human MASP-3 Monoclonal Antibody (TJL-218)(Cat#: CTMM-0322-JL2253)
This product is an unconjugated anti-Human Complement MASP-3 Monoclonal antibody (TJL-218) generated from the Mouse. The antibody can be used for WB.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
TJL-218 |
| Host Animal |
Mouse |
| Isotype |
IgG2b |
| Immunogen |
Recombinant Human Complement Factor MASP3, a.a. 450-721 |
| Species Reactivity |
Human |
| Applications |
WB |
| Application Notes |
WB: 1 ug/mL |
| Specificity |
This antibody reacts with Human Complement MASP-3. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
Unconjugated |
| Format |
Liquid |
| Size |
500 ug |
| Storage |
Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle. |
| Type |
Primary Antibody |
Target
| Target Name |
MASP3 |
| Alternative Names |
Mannose-Binding Lectin-Associated Serine Protease 3; Mannan Binding Lectin Serine Peptidase 1; Complement-Activating Component Of Ra-Reactive Factor ; Mannose-Binding Lectin-Associated Serine Protease 1; C4/C2 Activating Component Of Ra-Reactive Factor ; Mannan-Binding Lectin Serine Protease 1; Ra-Reactive Factor Serine Protease P100; Complement Factor MASP-3; CRARF; PRSS5; MASP; RaRF; MASP-1; MASP3; 3MC1; MAP1 |
| Gene ID |
5648 |
| UniProt ID |
P48740 |
Information
| Introduction |
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
