Mouse Anti-Human MASP1 Polyclonal Antibody(Cat#: CTA-458)
This product is an unconjugated anti-Human MASP1 Polyclonal antibody generated from the Mouse. The antibody can be used for WB; IF.
Summary
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Specifications
| Clonality |
Polyclonal |
| Host Animal |
Mouse |
| Isotype |
IgG |
| Immunogen |
MASP1 (1 a.a. - 380 a.a.) full-length human protein. MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIPTCKKNEIDLESELKSEQVTE |
| Species Reactivity |
Human |
| Applications |
WB; IF |
| Application Notes |
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Human MASP1. |
| Purity |
≥95% as determined by SDS-PAGE |
| Format |
Liquid |
| Size |
50 µg |
| Storage |
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Type |
Primary Antibody |
Target
| Target Name |
MASP1 |
| Alternative Names |
Mannan Binding Lectin Serine Peptidase 1; Complement-Activating Component Of Ra-Reactive Factor; Mannose-Binding Lectin-Associated Serine Protease 1; Mannose-Binding Protein-Associated Serine Protease; C4/C2 Activating Component Of Ra-Reactive Factor; Ra-Reactive Factor Serine Protease P100; Complement Factor MASP-3; Serine Protease; CRARF1; CRARF; PRSS5; RaRF; Mannan-Binding Lectin Serine Peptidase 1 (C4/C2 Activating Component Of Ra-Reactive Factor); Mannan-Binding Lectin Serine Protease 1 (C4/C2 Activating Component Of Ra-Reactive Factor); Mannan-Binding Lectin Serine Protease 1; EC 3.4.21.; MASP-1; MASP3; MAp44; 3MC1; MAP1; MASP |
| Gene ID |
5648 |
| UniProt ID |
P48740 |
Information
| Introduction |
Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene. MASP-1 is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 to form C4b2a, a C3-convertase. MASP-1 is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. MASP-1 is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. MASP-1 is also able to cleave fibrinogen and factor XIII and may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
