Mouse Anti-Rat CD11b/c Monoclonal Antibody (CTJS-67) [PE](Cat#: CTA-869)
This product is a conjugated anti-Rat CD11b/c Monoclonal antibody (CTJS-67) generated from the Mouse. The antibody can be used for FC.
Summary
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Specifications
| Clonality |
Monoclonal |
| Clone |
CTJS-67 |
| Host Animal |
Mouse |
| Isotype |
IgG2a κ |
| Immunogen |
Rat peritoneal macrophages |
| Species Reactivity |
Rat |
| Applications |
FC |
| Application Notes |
FC: 0.25 µg/10^6 cells
The optimal working dilutions should be determined by the end user. |
| Specificity |
This antibody reacts with Rat CD11b/c. |
| Purity |
≥95% as determined by SDS-PAGE |
| Conjugation |
PE |
| Format |
Liquid |
| Size |
50 µg |
| Storage |
Store in dark at 4°C. Do Not Freeze. |
| Type |
Primary Antibody |
Target
| Target Name |
CD11b/c |
| Alternative Names |
Integrin Subunit Alpha M; Complement Component 3 Receptor 3 Subunit; Integrin Alpha-M; CR-3 Alpha Chain; CD11B ; CR3A; Complement Component Receptor 3, Alpha; Neutrophil Adherence Receptor; Antigen; CD11b (P170); CD11b Antigen; ITGAM; CD11b; Integrin Subunit Alpha X; Integrin, Alpha X (Complement Component 3 Receptor 4 Subunit); Complement Component 3 Receptor 4 Subunit; Integrin Alpha-X; CD11C; Integrin Alpha X; CD11c Antigen; ITGAX; CD11c |
| Gene ID |
25021
499271 |
| UniProt ID |
G3V8L7
D3ZWZ1 |
Information
| Introduction |
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
