Native Human Complement C4b Binding Protein(Cat#: CTP-459)
This product is a human C4b binding protein (C4BP) which is purified from normal human serum. C4BP regulates complement activation of the classical and lectin pathways. It binds to C4b and accelerates the dissociation of C2a from the C3/C5 convertase C4b,C2a. This inactivates the central enzyme of both pathways. It also functions as a cofactor allowing factor I to cleave and permanently inactivate C4b.
Summary
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Specifications
| Specie Reactivity |
Human |
| Target |
C4b Binding Protein |
| Molecule Mass |
540 kDa |
| Purity |
>90 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
10 mM sodium phosphate, 145 mM NaCl, pH 7.2 |
| Applications |
Functional Assays |
| Product Form |
Frozen liquid |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
C4b Binding Protein (C4BP) is a large glycoprotein complex involved in the complement activity inhibition. C4BP is composed of α-chains (C4BPA) and β-chain (C4BPB),presenting an octopus-like structure. C4BP inhibits the cascade of the classical and the lectin pathways by binding to C4b and C3b. It also accelerates decay of C3-convertase and is a cofactor for serine protease factor I which cleaves C4b and C3b. |
| Alternative Names |
C4BP; C4b-Binding Protein |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
