Native Human Complement iC3b Protein(Cat#: CTP-524)
This product is a 176 kDa native human iC3b protein isolated from normal human serum.
Summary
Related Products & Services
Specifications
| Specie Reactivity |
Human |
| Target |
iC3b |
| Molecule Mass |
176 kDa |
| Purity |
>90 % determined by SDS-PAGE |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
10 mM sodium phosphate, 145 mM NaCl, pH 7.2 |
| Product Form |
Frozen liquid |
| Storage |
Store at -20°C/-80°C. Avoid freeze-thaw cycles. |
Protein Information
| Introduction |
Complement iC3b is an inactive form of C3b, which is formed through the cleavage of C3b by factor I in the presence of factor H. Complement receptors on white blood cells are able to bind iC3b, so iC3b functions as an opsonin. Unlike intact C3b, iC3b cannot associate with factor B, thus preventing amplification of the complement cascade through the alternative pathway. Complement factor I can further cleave iC3b into a protein fragment known as C3d. |
| Alternative Names |
inactive C3b; inactivated C3b; iC3b fragment |
| Gene ID |
718 |
| UniProt ID |
P01024 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
