Native Human Complement iC3b Protein(Cat#: CTP-524)

Name: Native Human Complement iC3b Protein
SKU: CTP-524
Rating: 5 (1 reviews)

This product is a 176 kDa native human iC3b protein isolated from normal human serum.

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Specifications

Specie Reactivity	Human
Target	iC3b
Molecule Mass	176 kDa
Purity	>90 % determined by SDS-PAGE
Endotoxin	<1.0EU per 1µg (determined by the LAL method)
Formulation	10 mM sodium phosphate, 145 mM NaCl, pH 7.2
Product Form	Frozen liquid
Storage	Store at -20°C/-80°C. Avoid freeze-thaw cycles.

Protein Information

Introduction	Complement iC3b is an inactive form of C3b, which is formed through the cleavage of C3b by factor I in the presence of factor H. Complement receptors on white blood cells are able to bind iC3b, so iC3b functions as an opsonin. Unlike intact C3b, iC3b cannot associate with factor B, thus preventing amplification of the complement cascade through the alternative pathway. Complement factor I can further cleave iC3b into a protein fragment known as C3d.
Alternative Names	inactive C3b; inactivated C3b; iC3b fragment
Gene ID	718
UniProt ID	P01024

For Research Use Only. Not for Diagnostic or Therapeutic Applications.