Native Mouse Complement iC3b Protein(Cat#: CTMM-2410-JL6)

Name: Native Mouse Complement iC3b Protein
SKU: CTMM-2410-JL6
Rating: 5 (1 reviews)

This product is a 175 kDa native mouse iC3b protein isolated from normal mouse serum. It is availible for functional assays.

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Specifications

Expressed Host	Normal mouse serum
Target	C3b
Molecule Mass	175 kDa (3 chains)
Purity	> 85% by SDS PAGE
Formulation	10 mM sodium phosphate, 145 mM NaCl, pH 7.2
Applications	Functional Assays
Product Form	Frozen liquid
Storage	Store at -80°C. Avoid repeated freeze-thaw cycles.

Protein Information

Introduction	Mouse iC3b is prepared by cleavage of mouse C3b by factor I in the presence of factor H. Conversion of C3b to iC3b destroys nearly all functional binding sites on C3b. Surface-bound iC3b and its breakdown product C3d are recognized by a number of receptors on lymphocytes and phagocytes that use these ligands to stimulate phagocytosis and antigen presentation to cells of the adaptive immune system. The receptors for iC3b are CD21 on B cells and CD11b/CD18 on phagocytes. One of the results of iC3b-receptor interactions is the expansion of target-specific B and T cell populations.
Alternative Names	Mouse Complement iC3b Protein; iC3b (Mouse)
Gene ID	12266
UniProt ID	P01027

For Research Use Only. Not for Diagnostic or Therapeutic Applications.