Native Rat Complement Factor H Protein(Cat#: CTMM-0123-MM32)

Name: Native Rat Complement Factor H Protein
SKU: CTMM-0123-MM32

This product is a Rat factor H protein which is purified from rat serum. It is an essential regulatory component of the alternative pathway of complement. It has two functional activities: 1) it controls the formation and decay of the alternative pathway C3/C5 convertase (decay accelerating activity) and 2) it acts as a cofactor for factor I which proteolytically inactivates C3b when C3b is bound to factor H (cofactor activity).

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Specifications

Specie Reactivity	Rat
Target	Factor H
Molecule Mass	155 kDa
Purity	>90% determined by SDS-PAGE
Formulation	10 mM sodium phosphate, 145 mM NaCl, pH 7.3
Applications	Functional Assays
Product Form	Frozen liquid
Storage	Store at -80°C. Avoid freeze-thaw cycles.

Protein Information

Introduction	Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.
Alternative Names	Complement Factor H; Age-Related Maculopathy Susceptibility 1; H Factor (Complement); Beta-1H; FHL1 ; Adrenomedullin Binding Protein; Beta-1-H-Globulin; H Factor; Factor H; CFH; FH
Gene ID	3075
UniProt ID	P08603

Customer Review

Highly recommended for those studying the complement system

Excellent

Its high purity and functionality in our assays have allowed us to make significant progress in understanding complement regulation. The protein performed consistently across multiple experiments, which is crucial for reproducibility.

It's a bit pricey, but the quality justifies the cost

Excellent

We've used this protein in several functional assays, and it's been exceptional. The quality was evident in the clear, well-defined bands during Western blotting. Our results were reproducible and aligned with expected outcomes, making this a reliable product for our research needs.

I was impressed with the protein's performance

Excellent

The protein's activity was robust in our assays, and it helped us decipher the role of factor H in complement regulation effectively. Packaging and delivery were also excellent. A great addition to any lab studying complement pathways.

The purity and biological activity were evident

Excellent

It integrates seamlessly into our assays, and the results have been highly reproducible. The quality control seems stringent, as evidenced by the consistent data we've obtained. Worth every penny for serious complement research.

If you're working on complement research, this product is a solid choice

Excellent

We observed precise interactions with other complement components, which has advanced our understanding of complement regulation. The protein's stability and functionality have exceeded our expectations.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.