Rabbit Anti-Human Collectin-11 Polyclonal Antibody(Cat#: CTA-1089)

Name: Rabbit Anti-Human Collectin-11 Polyclonal Antibody
SKU: CTA-1089
Rating: 5 (1 reviews)

This product is an unconjugated anti-Human Collectin-11 Polyclonal antibody generated from the Rabbit. The antibody can be used for WB, IHC, FC.

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Specifications

Clonality	Polyclonal
Host Animal	Rabbit
Isotype	IgG
Immunogen	Recombinant human COLEC11
Species Reactivity	Human
Applications	WB; IHC; FC
Application Notes	WB: 1:500-1:1000 IHC: 1:20-1:50 FC: 1:20-1:50 The optimal working dilutions should be determined by the end user.
Specificity	This antibody reacts with Human Collectin-11.
Purity	≥95% as determined by SDS-PAGE
Conjugation	Unconjugated
Format	Liquid
Size	100; 200 µL
Storage	Store at 4°C for short term. Store at -20°C for long term. Avoid freeze-thaw cycle.
Type	Primary Antibody

Target

Target Name	Collectin-11
Alternative Names	Collectin Subfamily Member 11; Collectin Kidney Protein 1; Collectin K1; Collectin-11; CL-K1; Collectin Sub-Family Member 11; CL-K1-Iia; CL-K1-Iib; CL-K1-II; COLEC11; 3MC2; CLK1
Gene ID	78989
UniProt ID	Q9BWP8

Information

Introduction

Collectin-11 (CL-11) is a lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.